Fisetin
Senolytic flavonoid from strawberries. Selectively kills senescent (zombie) cells. The most-promising senolytic from a safety profile standpoint.
What it actually is
Not a peptide. Fisetin is a flavonol polyphenol found in strawberries, apples, persimmons, and onions. It selectively triggers apoptosis in senescent cells — cells that have stopped dividing but secrete inflammatory signals. Senescent cell accumulation is a hallmark of aging.
Why peptide users come across it
The leading practical senolytic. Mayo Clinic ran human safety trials. Often dosed in 'hit-and-run' protocols — high doses for 2 days, then off for weeks/months. Pairs with quercetin and dasatinib in the dasatinib-quercetin senolytic protocol.
Mechanism
Documented dose range
Side effects
Contraindications
The Pepdex take
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