Longevity & biohacking adjuncts
These aren't peptides. They're the small molecules, coenzymes, and antioxidants that show up in the same conversations as peptides — NAD+, NMN, Methylene Blue, Glutathione, and more. Same Pepdex discipline: documented dose ranges, documented side effects, regulatory status flagged, and no vendor recommendations.
Coenzyme central to energy metabolism and DNA repair. Levels decline with age. The most-discussed longevity adjunct in the peptide community.
Direct NAD+ precursor. Oral. The most-purchased longevity supplement in the peptide-adjacent community. Cheaper and easier than IV NAD+.
Alternative-electron-acceptor dye that supports mitochondrial respiration. Cheap, effective, weirdly under-prescribed. Surprisingly broad use in cognition and cellular bioenergetics protocols.
Amino-acid derivative that shuttles long-chain fatty acids into mitochondria for ATP production. The classic 'fat-loss' supplement that has actual mechanism — when dosed correctly.
Acetylated L-Carnitine. Crosses the blood-brain barrier. The cognitive sibling of L-Carnitine — same shuttle role plus a brain layer.
Polyamine that triggers autophagy — the cellular cleanup process. Naturally occurring in wheat germ and aged cheese. The longevity-research darling of the late 2010s.
Another NAD+ precursor. ChromaDex's branded form (Niagen) is the most-studied. Competes with NMN for the 'oral path to NAD+' market.
Polyphenol from red wine that activates sirtuins. The molecule that launched the modern longevity supplement industry. Bioavailability is the catch.
Senolytic flavonoid from strawberries. Selectively kills senescent (zombie) cells. The most-promising senolytic from a safety profile standpoint.
Flavonoid antioxidant. Co-senolytic with fisetin or dasatinib. Anti-allergic and anti-viral support, popular as a daily polyphenol.
Plant alkaloid that acts on AMPK — basically nature's metformin. Heavily marketed as a 'GLP-1 alternative' (questionable claim), but the metabolic effects are real.
The body's master antioxidant. Technically a tripeptide but functions more like a small-molecule biohacking adjunct. Often paired with NAD+ in IV protocols.