Spermidine
Polyamine that triggers autophagy — the cellular cleanup process. Naturally occurring in wheat germ and aged cheese. The longevity-research darling of the late 2010s.
What it actually is
Not a peptide. Spermidine is a polyamine (small organic molecule with multiple amine groups), produced naturally in cells and present in food. It directly activates autophagy — the process by which cells digest damaged organelles and proteins. Levels decline materially with age.
Why peptide users come across it
The autophagy hook makes it a longevity-stack staple. Often paired with NMN/NR (NAD+ precursors) and rapamycin alternatives. Heavily promoted by longevity-podcast circuits in the late 2010s and early 2020s.
Mechanism
Documented dose range
Side effects
Contraindications
The Pepdex take
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