NAD+ (Nicotinamide Adenine Dinucleotide)
Coenzyme central to energy metabolism and DNA repair. Levels decline with age. The most-discussed longevity adjunct in the peptide community.
What it actually is
Not a peptide. NAD+ is a dinucleotide — two nucleotides joined together — that every cell uses to run its energy machinery and repair systems. It's a coenzyme for sirtuins (longevity-related enzymes), PARPs (DNA repair), and the entire mitochondrial electron-transport chain. Cellular NAD+ levels drop materially with age, and the working hypothesis driving the longevity research is that restoring those levels improves cellular function.
Why peptide users come across it
Pairs naturally with peptide protocols targeting recovery, energy, and aging. The Sinclair lab popularized it. IV NAD+ clinics opened in major cities. Often stacked with growth-axis peptides (Sermorelin, Tesamorelin, MOTS-c) and SS-31.
Mechanism
Documented dose range
Side effects
Contraindications
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