Coenzyme / NAD axisModerate evidenceNot a peptide

NMN (Nicotinamide Mononucleotide)

Direct NAD+ precursor. Oral. The most-purchased longevity supplement in the peptide-adjacent community. Cheaper and easier than IV NAD+.

What it actually is

Not a peptide. NMN is one biosynthetic step away from NAD+, your cells convert it directly. Sold as an oral capsule or sublingual powder. The whole appeal is that it's a substrate route to raising NAD+ without the IV.

Why peptide users come across it

Lower-friction alternative to IV NAD+. David Sinclair takes ~1 g/day. Often stacked with resveratrol or pterostilbene (sirtuin activators). Common entry point into the longevity-supplement scene.

Mechanism

Crosses cell membrane via the Slc12a8 transporter (debated), then converted to NAD+ by NMNAT enzymes. Net effect: raises intracellular NAD+ pool, especially in tissues with high turnover.

Documented dose range

Members only

Side effects

Mild GI upset on empty stomach (take with food if it bothers you)
Vivid dreams in a subset of users
Transient fatigue in first 1-2 weeks
Histamine-flush reactions in mast-cell-sensitive users (rare)

Contraindications

Active cancer (theoretical, same NAD+ caveat applies)
Pregnancy and breastfeeding

The Pepdex take

Sublingual is debated to absorb better than oral, but the absorption math suggests the difference is small. Buying from a manufacturer that does third-party purity testing matters more than the form factor. NMN itself is unstable to heat, fridge storage extends shelf life.

Turn NMN (Nicotinamide Mononucleotide) into a plan that's yours

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