Stack essentials
What to take with your peptides.
Every entry below pairs with a specific peptide protocol for a documented mechanistic reason. Deficiencies your peptide creates. Side effects you can pre-empt. Synergies that aren't optional if you want full results. Not a generic supplement catalog.
Deficiency fixPairs with 3 peptides
Thiamine (Vitamin B1)
GLP-1 users frequently run B1-deficient because the appetite drop kills food intake before nutrient targets are met.
Deficiency fixPairs with 5 peptides
Magnesium (Glycinate)
Electrolyte that drops with GLP-1 GI side effects and high-dose injection cycles.
Deficiency fixPairs with 3 peptides
Potassium
Primary electrolyte lost during GLP-1 vomiting/diarrhea, most underrated supplement for this class.
Side-effect fixPairs with 3 peptides
Psyllium Husk Fiber
GI normalizer for GLP-1 users, handles constipation and stabilizes blood sugar.
Side-effect fixPairs with 3 peptides
Electrolyte Powder (LMNT-style)
Single-stick fix for sodium/potassium/magnesium loss during early-cycle GLP-1 fatigue.
SynergyPairs with 4 peptides
Creatine Monohydrate
Muscle-preservation insurance during GLP-1-driven weight loss.
Side-effect fixPairs with 1 peptide
TUDCA (Tauroursodeoxycholic Acid)
Liver and bile-flow support, relevant if stacking peptides with anything orally hepatotoxic.
SynergyPairs with 6 peptides
Vitamin D3 + K2
Baseline hormone-axis support that becomes more important on GH-secretagogue stacks.
SynergyPairs with 5 peptides
Omega-3 (EPA/DHA)
Background anti-inflammatory that pairs with healing peptides and supports joint outcomes.
MonitoringPairs with 5 peptides
Continuous Glucose Monitor (CGM)
Two-week data on how YOUR glucose responds to a peptide protocol. Most underrated tool in the space.
The full supplement catalog
Every supplement Pepdex covers, each with an honest evidence tier and the real citation count behind it — including the vitamins and minerals most people are actually taking.
Foundation
The boring ones with the most human data.
- B-complexThe remaining B vitamins, which are genuinely essential and almost never individually deficient on a normal diet.Limited
- BiotinA hair-and-nails staple that helps almost nobody — and can make your blood tests lie.Limited
- BoronA trace mineral with a small hormonal literature that the supplement world has considerably oversold.Limited
- CalciumEssential for bone, best obtained from food, and the supplement form carries a cardiovascular question the food form does not.Moderate
- CopperRarely supplemented on purpose, frequently depleted by accident — usually by zinc.Moderate
- Desiccated organ supplementsFreeze-dried organ meat in a capsule — genuinely nutrient-dense, with claims that run well past the nutrition.Anecdotal
- ElderberryThe cold-season standby, with small positive trials and one genuine theoretical caution.Limited
- ElectrolytesSalts lost through sweat and, notably, through GLP-1 appetite suppression and low food intake.Strong
- Folate (B9)One of the few supplements with a proven, population-scale preventive effect — and one specific interaction that matters.Strong
- IodineEssential for thyroid hormone, and one of the few nutrients where too much causes the same disease as too little.Strong
- IronThe one supplement on this list that can genuinely transform how someone feels — and the one most dangerous to take without a test.Strong
- MulleinA traditional respiratory herb that went viral for "lung cleansing" with essentially no human trials behind it.Anecdotal
- MultivitaminCheap insurance against gaps, repeatedly unable to prove it does anything beyond that.Limited
- NACA glutathione precursor with a genuine hospital pedigree and a much thinner case for the things it is sold for.Moderate
- SeleniumAn essential trace mineral with an unusually narrow window between too little and too much.Moderate
- Vitamin AEssential, and the fat-soluble vitamin most capable of doing serious harm in excess.Strong
- Vitamin B12Essential, cheap, and dramatic to fix when deficient — placebo-tier energy shots when you are not.Strong
- Vitamin B6Essential, useful in a couple of narrow situations, and the one water-soluble vitamin that reliably causes nerve damage in excess.Moderate
- Vitamin CFully essential, rarely deficient in the developed world, and mostly oversold above dietary doses.Strong
- Vitamin D3Fat-soluble vitamin most people are low in through winter. Corrects a deficiency; it is not a performance drug.Strong
- Vitamin EThe antioxidant that best illustrates why "antioxidant" is not the same as "good for you".Moderate
- Vitamin K2Directs calcium toward bone and away from arteries in theory; the human outcome data is thinner than the pairing with D3 implies.Limited
- ZincTrace mineral involved in immune function and hormone pathways.Moderate
Performance
Training output, strength, recovery.
- BCAA / EAAAmino-acid supplements whose benefit shrinks toward zero once total protein intake is adequate — the trials keep saying so.Limited
- Beta-alanineBuffers acid in the 1–4 minute effort range. Causes the harmless skin tingle.Strong
- CaffeineThe most effective legal stimulant, and the easiest one to build tolerance to.Strong
- Collagen peptidesDigested to amino acids like any protein — yet the skin and tendon trials keep coming out mildly positive anyway.Moderate
- L-carnitineA fat-transport molecule with decent evidence in specific niches — and an injectable gym version that outruns the data.Moderate
- L-citrullineNitric-oxide precursor studied for training volume and the pump.Moderate
- TMG (betaine)A methyl donor with one well-established effect and one popular claim that keeps not replicating.Moderate
- Whey proteinA convenient protein source, not a drug. Matters only if you are missing daily protein.Strong
Sleep
Falling asleep, staying asleep, sleep quality.
- ApigeninChamomile flavonoid popularised by podcast sleep stacks.Anecdotal
- GlycineSimple amino acid studied for subjective sleep quality and next-day fatigue.Limited
- L-theanineAmino acid from tea, studied for taking the edge off stimulants without sedating you.Moderate
- MelatoninA timing signal, not a sedative. Best evidence is for shifting your clock, not knocking you out.Strong
Brain
Focus, memory, stress load.
- AshwagandhaAdaptogenic herb studied for perceived stress and cortisol.Moderate
- Choline (Alpha-GPC / CDP-choline)Acetylcholine precursors — the standard "stack base" nootropics, with modest real evidence and one cardiovascular question mark.Moderate
- DHA (brain)The structural omega-3 that concentrates in brain tissue.Moderate
- L-tyrosineDopamine precursor studied under acute stress — cold, sleep loss, heavy multitasking.Limited
- Lion's maneMushroom extract promoted for nerve growth factor and memory.Limited
- Rhodiola roseaAn adaptogen with a small, mostly Eastern European literature suggesting it helps fatigue more than stress.Limited
- Saffron extractA spice extract with small randomized trials in low mood — modest reported effects, limited replication.Moderate
Gut
Digestion, bloating, regularity.
- Enteric peppermint oilAntispasmodic studied specifically for IBS pain and bloating.Moderate
- L-glutamineAmino acid promoted for intestinal lining repair.Limited
- PrebioticsFood for the bacteria you already have, rather than more bacteria — and the distinction is the whole point.Moderate
- ProbioticsLive bacteria. Effects are strain-specific — "probiotic" alone tells you nothing.Moderate
- Psyllium huskSoluble fibre studied for regularity, cholesterol and satiety.Strong
Inflammation
Joint and systemic inflammatory markers.
- CurcuminTurmeric-derived compound studied for joint pain and inflammatory markers.Moderate
- Glucosamine, chondroitin & MSMThe joint-aisle mainstays, and the ones with the largest, most disappointing trial ever run against them.Limited
- PEAAn endogenous fatty-acid amide studied in chronic pain — modest reported benefit, limited adverse-event reporting.Moderate
- Tart cherryPolyphenol-rich extract studied for muscle soreness and sleep.Moderate
Metabolic
Glucose, lipids, body composition.
- BerberinePlant alkaloid studied for blood glucose and lipids. Marketed dishonestly as "natural Ozempic" — it is not.Moderate
- ChromiumA long-standing blood-sugar and cravings claim that repeated trials have mostly failed to support.Limited
- DIMA broccoli-derived compound sold for "estrogen balance" on largely preclinical grounds.Limited
- Myo-inositolSugar alcohol studied mainly in PCOS for insulin sensitivity and cycle regularity.Moderate
- Niacin (B3)Moves lipid numbers convincingly and failed to move outcomes — the clearest surrogate-endpoint lesson in this catalog.Moderate
- Soluble fibreBlunts glucose response and adds satiety — the least glamorous, best-supported intervention here.Strong
Longevity
The long-horizon bets. Evidence is thinnest here.
- AstaxanthinThe carotenoid that makes salmon pink, sold for skin and endurance on early evidence.Limited
- CoQ10Mitochondrial cofactor, best studied in statin users and heart failure.Moderate
- FisetinA strawberry flavonoid with striking mouse data and, so far, almost no human data.Limited
- GlutathioneThe body's master antioxidant — heavily marketed injectable and oral, with an absorption story more complicated than the labels admit.Limited
- Lutein & zeaxanthinEye-health carotenoids with a rare distinction in this aisle: a large, well-run trial behind them.Moderate
- Methylene blueA century-old dye and medication now promoted as a nootropic and mitochondrial aid.Anecdotal
- Milk thistleThe default "liver supplement", with a trial record far more ambiguous than its reputation.Limited
- NMN / NRNAD+ precursors sold on a very large promise built on a very small human base.Limited
- QuercetinA common plant flavonoid, popular first for immunity and now as half of a senolytic pair.Limited
- Reishi & cordycepsThe functional-mushroom aisle beyond lion's mane — long traditional use, thin modern trials.Limited
- ResveratrolThe molecule that launched the longevity supplement industry, and the one whose original science was retracted.Limited
- SpermidineAn autophagy-inducing polyamine found in wheat germ and aged cheese, with early human work.Limited
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