Stack essentials
What to take with your peptides.
Every entry below pairs with a specific peptide protocol for a documented mechanistic reason. Deficiencies your peptide creates. Side effects you can pre-empt. Synergies that aren't optional if you want full results. Not a generic supplement catalog.
Deficiency fixPairs with 3 peptides
Thiamine (Vitamin B1)
GLP-1 users frequently run B1-deficient because the appetite drop kills food intake before nutrient targets are met.
Deficiency fixPairs with 5 peptides
Magnesium (Glycinate)
Electrolyte that drops with GLP-1 GI side effects and high-dose injection cycles.
Deficiency fixPairs with 3 peptides
Potassium
Primary electrolyte lost during GLP-1 vomiting/diarrhea, most underrated supplement for this class.
Side-effect fixPairs with 3 peptides
Psyllium Husk Fiber
GI normalizer for GLP-1 users, handles constipation and stabilizes blood sugar.
Side-effect fixPairs with 3 peptides
Electrolyte Powder (LMNT-style)
Single-stick fix for sodium/potassium/magnesium loss during early-cycle GLP-1 fatigue.
SynergyPairs with 4 peptides
Creatine Monohydrate
Muscle-preservation insurance during GLP-1-driven weight loss.
Side-effect fixPairs with 1 peptide
TUDCA (Tauroursodeoxycholic Acid)
Liver and bile-flow support, relevant if stacking peptides with anything orally hepatotoxic.
SynergyPairs with 6 peptides
Vitamin D3 + K2
Baseline hormone-axis support that becomes more important on GH-secretagogue stacks.
SynergyPairs with 5 peptides
Omega-3 (EPA/DHA)
Background anti-inflammatory that pairs with healing peptides and supports joint outcomes.
MonitoringPairs with 5 peptides
Continuous Glucose Monitor (CGM)
Two-week data on how YOUR glucose responds to a peptide protocol. Most underrated tool in the space.
The full supplement catalog
Every supplement Pepdex covers, each with an honest evidence tier and the real citation count behind it — including the vitamins and minerals most people are actually taking.
Foundation
The boring ones with the most human data.
- Algae omega-3DHA and EPA from microalgae, the plant-based route to the same fatty acids fish carry.Moderate
- B-complexThe remaining B vitamins, which are genuinely essential and almost never individually deficient on a normal diet.Limited
- BiotinA hair-and-nails staple that helps almost nobody, and can make your blood tests lie.Limited
- Bone broth proteinDried broth sold as collagen and joint support; it is a protein powder with a collagen-heavy amino profile.Anecdotal
- BoronA trace mineral with a small hormonal literature that the supplement world has considerably oversold.Limited
- CalciumEssential for bone, best obtained from food, and the supplement form carries a cardiovascular question the food form does not.Moderate
- ChlorellaA freshwater algae sold for detox and immunity; the detox claim is not supported in people.Limited
- Cod liver oilFish oil that also carries preformed vitamin A and vitamin D, which is the point and the catch.Moderate
- CopperRarely supplemented on purpose, frequently depleted by accident, usually by zinc.Moderate
- Desiccated organ supplementsFreeze-dried organ meat in a capsule, genuinely nutrient-dense, with claims that run well past the nutrition.Anecdotal
- EchinaceaThe cold remedy herb; pooled trials show a small reduction in cold incidence and little effect on duration.Limited
- ElderberryThe cold-season standby, with small positive trials and one genuine theoretical caution.Limited
- ElectrolytesSalts lost through sweat and, notably, through GLP-1 appetite suppression and low food intake.Strong
- Evening primrose oilA GLA-rich seed oil sold for PMS, eczema and breast pain, where the trials mostly came back negative.Limited
- Folate (B9)One of the few supplements with a proven, population-scale preventive effect, and one specific interaction that matters.Strong
- Greens powderA scoop of dried vegetables, algae, probiotics and vitamins marketed as insurance against a bad diet.Anecdotal
- IodineEssential for thyroid hormone, and one of the few nutrients where too much causes the same disease as too little.Strong
- IronThe one supplement on this list that can genuinely transform how someone feels, and the one most dangerous to take without a test.Strong
- Krill oilOmega-3s bound to phospholipids with astaxanthin along for the ride; smaller doses than fish oil, priced higher.Limited
- L-lysineAn essential amino acid sold mainly for cold sores, on old and mixed trials.Limited
- Magnesium oxideThe cheapest magnesium and the least absorbed; fine as a laxative, weak as a supplement.Limited
- ManganeseA trace mineral for bone and enzyme function that almost nobody is short of and that is toxic in excess.Limited
- MolybdenumA trace mineral cofactor for sulfite handling that a normal diet covers many times over.Limited
- MulleinA traditional respiratory herb that went viral for "lung cleansing" with essentially no human trials behind it.Anecdotal
- MultivitaminCheap insurance against gaps, repeatedly unable to prove it does anything beyond that.Limited
- NACA glutathione precursor with a genuine hospital pedigree and a much thinner case for the things it is sold for.Moderate
- Prenatal multivitaminA multivitamin built around folate, iron, iodine and choline for pregnancy and the months before it.Strong
- Saw palmettoThe classic prostate herb, which the best trials say does no better than placebo for urinary symptoms.Limited
- Sea mossA red seaweed gel that went viral for its mineral content; iodine is the one nutrient it reliably carries.Anecdotal
- SeleniumAn essential trace mineral with an unusually narrow window between too little and too much.Moderate
- SpirulinaA blue-green algae dense in protein and pigments, with a small trial literature on lipids and immune markers.Limited
- Vitamin AEssential, and the fat-soluble vitamin most capable of doing serious harm in excess.Strong
- Vitamin B12Essential, cheap, and dramatic to fix when deficient, placebo-tier energy shots when you are not.Strong
- Vitamin B6Essential, useful in a couple of narrow situations, and the one water-soluble vitamin that reliably causes nerve damage in excess.Moderate
- Vitamin CFully essential, rarely deficient in the developed world, and mostly oversold above dietary doses.Strong
- Vitamin D3Fat-soluble vitamin most people are low in through winter. Corrects a deficiency; it is not a performance drug.Strong
- Vitamin EThe antioxidant that best illustrates why "antioxidant" is not the same as "good for you".Moderate
- Vitamin K2Directs calcium toward bone and away from arteries in theory; the human outcome data is thinner than the pairing with D3 implies.Limited
- VitexA berry extract with several trials for premenstrual symptoms and cycle irregularity.Moderate
- ZincTrace mineral involved in immune function and hormone pathways.Moderate
Performance
Training output, strength, recovery.
- BCAA / EAAAmino-acid supplements whose benefit shrinks toward zero once total protein intake is adequate, the trials keep saying so.Limited
- Beetroot nitrateDietary nitrate from beets, one of the few endurance supplements with a consistent effect.Moderate
- Beta-alanineBuffers acid in the 1-4 minute effort range. Causes the harmless skin tingle.Strong
- CaffeineThe most effective legal stimulant, and the easiest one to build tolerance to.Strong
- Casein proteinThe slow milk protein; it digests over hours, which is why it is the classic bedtime shake.Moderate
- Collagen peptidesDigested to amino acids like any protein, yet the skin and tendon trials keep coming out mildly positive anyway.Moderate
- CordycepsA mushroom sold for endurance and oxygen use, with a few small, mixed exercise trials.Limited
- Fadogia agrestisA Nigerian shrub that raised testosterone in rats and has essentially no human data.Anecdotal
- HMBA leucine metabolite sold for muscle retention; the strong early trials have not held up in later, better-run ones.Limited
- L-arginineA nitric-oxide precursor that citrulline largely replaced, because most of an oral dose is broken down in the gut and liver.Limited
- L-carnitineA fat-transport molecule with decent evidence in specific niches, and an injectable gym version that outruns the data.Moderate
- L-citrullineNitric-oxide precursor studied for training volume and the pump.Moderate
- MacaAn Andean root with a small, real libido signal and no effect on hormones.Limited
- ShilajitA Himalayan mineral tar with fulvic acid, sold for testosterone and energy on a few small trials.Limited
- Sodium bicarbonateBaking soda as a buffer for hard 1-10 minute efforts; effective and famously hard on the stomach.Moderate
- TaurineAn amino acid abundant in muscle and heart, sold for endurance, blood pressure and as the thing in energy drinks that is not caffeine.Limited
- TheacrineA caffeine cousin from kucha tea with a slower onset and, per small industry trials, less tolerance.Limited
- TMG (betaine)A methyl donor with one well-established effect and one popular claim that keeps not replicating.Moderate
- Tongkat aliA Malaysian root sold for testosterone and libido, with small trials mostly in stressed or older men.Limited
- Tribulus terrestrisA testosterone booster by reputation that does not raise testosterone in any human trial.Limited
- Whey proteinA convenient protein source, not a drug. Matters only if you are missing daily protein.Strong
Sleep
Falling asleep, staying asleep, sleep quality.
- 5-HTPThe direct serotonin precursor, sold for mood, sleep and appetite.Limited
- ApigeninChamomile flavonoid popularised by podcast sleep stacks.Anecdotal
- ChamomileThe tea herb, with small trials on anxiety and sleep that point the right way without proving much.Limited
- GABAThe brain's main calming neurotransmitter, taken orally, where most of it may not reach the brain.Limited
- GlycineSimple amino acid studied for subjective sleep quality and next-day fatigue.Limited
- L-theanineAmino acid from tea, studied for taking the edge off stimulants without sedating you.Moderate
- MelatoninA timing signal, not a sedative. Best evidence is for shifting your clock, not knocking you out.Strong
- ReishiA bitter mushroom with a long tradition for calm and immunity and thin modern data.Limited
- ValerianThe traditional sleep herb, with trials that lean positive on self-report and neutral on measured sleep.Limited
Brain
Focus, memory, stress load.
- Alpha-GPCA choline source that reaches the brain, with small trials on power output and memory.Limited
- AshwagandhaAdaptogenic herb studied for perceived stress and cortisol.Moderate
- Bacopa monnieriAn Ayurvedic herb with a repeatable memory benefit that takes weeks to show.Moderate
- Choline (Alpha-GPC / CDP-choline)Acetylcholine precursors, the standard "stack base" nootropics, with modest real evidence and one cardiovascular question mark.Moderate
- DHA (brain)The structural omega-3 that concentrates in brain tissue.Moderate
- Ginkgo bilobaThe most-studied memory herb, and the large trials did not find it prevents cognitive decline.Limited
- Huperzine AA potent acetylcholinesterase inhibitor from a moss, sold in nootropic stacks at drug-like activity.Limited
- L-tyrosineDopamine precursor studied under acute stress, cold, sleep loss, heavy multitasking.Limited
- Lion's maneMushroom extract promoted for nerve growth factor and memory.Limited
- Magnesium L-threonateThe magnesium form marketed for the brain on the strength of rodent data and a couple of small human trials.Limited
- Panax ginsengThe classic ginseng, with small trials on fatigue, mental performance and erectile function.Limited
- PhosphatidylserineA membrane phospholipid with small trials on memory in older adults and cortisol after exercise.Limited
- Rhodiola roseaAn adaptogen with a small, mostly Eastern European literature suggesting it helps fatigue more than stress.Limited
- Saffron extractA spice extract with small randomized trials in low mood, modest reported effects, limited replication.Moderate
Gut
Digestion, bloating, regularity.
- Betaine HClA stomach-acid supplement based on the belief that low acid causes reflux and bloating.Anecdotal
- Dandelion rootA bitter root with a folk reputation for liver support and a mild diuretic effect shown in one tiny study.Anecdotal
- Digestive enzymesBlends of the enzymes the pancreas makes, sold for bloating; useful when a specific enzyme is missing.Limited
- Enteric peppermint oilAntispasmodic studied specifically for IBS pain and bloating.Moderate
- GingerThe best-evidenced natural anti-nausea agent, with a smaller body of data on muscle soreness and inflammation.Moderate
- L-glutamineAmino acid promoted for intestinal lining repair.Limited
- Magnesium citrateA well-absorbed magnesium form that also draws water into the bowel, which is why it doubles as a laxative.Moderate
- PrebioticsFood for the bacteria you already have, rather than more bacteria, and the distinction is the whole point.Moderate
- ProbioticsLive bacteria. Effects are strain-specific, "probiotic" alone tells you nothing.Moderate
- Psyllium huskSoluble fibre studied for regularity, cholesterol and satiety.Strong
- Saccharomyces boulardiiA probiotic yeast, not a bacterium, with the best evidence of any probiotic for antibiotic and traveler's diarrhea.Moderate
- Zinc carnosineA zinc-carnosine complex used in Japan as a stomach-lining drug, with trials on ulcers and gut irritation.Moderate
Inflammation
Joint and systemic inflammatory markers.
- BoswelliaA resin extract with a consistent osteoarthritis signal in short trials.Moderate
- Chondroitin sulfateA cartilage component with decades of osteoarthritis trials that disagree depending on who paid for them.Limited
- CurcuminTurmeric-derived compound studied for joint pain and inflammatory markers.Moderate
- Glucosamine, chondroitin & MSMThe joint-aisle mainstays, and the ones with the largest, most disappointing trial ever run against them.Limited
- Hyaluronic acidThe joint-fluid and skin molecule, taken orally, where small trials suggest some of it gets where it is meant to go.Limited
- MSMA sulfur compound sold for joints and skin, with a few small osteoarthritis trials behind it.Limited
- PEAAn endogenous fatty-acid amide studied in chronic pain, modest reported benefit, limited adverse-event reporting.Moderate
- SerrapeptaseA silkworm enzyme sold for inflammation and sinus congestion, with mostly old, low-quality trials.Anecdotal
- Tart cherryPolyphenol-rich extract studied for muscle soreness and sleep.Moderate
Metabolic
Glucose, lipids, body composition.
- Aged garlic extractOdorless garlic concentrate with a consistent, small blood pressure effect in hypertensive adults.Moderate
- Alpha-lipoic acidAn antioxidant with real trial data for diabetic nerve pain and a weaker case for glucose and weight.Moderate
- Apple cider vinegarVinegar sold for blood sugar and weight; the liquid has a small glucose effect, the gummies have almost no acetic acid.Limited
- BerberinePlant alkaloid studied for blood glucose and lipids. Marketed dishonestly as "natural Ozempic", it is not.Moderate
- Black seed oilA seed oil with a surprising number of small trials on blood pressure, glucose and lipids.Limited
- ChromiumA long-standing blood-sugar and cravings claim that repeated trials have mostly failed to support.Limited
- CinnamonA spice with a modest fasting-glucose signal in type 2 diabetes and a coumarin problem in the common variety.Limited
- CLAA fatty acid that leaned out animals dramatically and people barely.Limited
- DIMA broccoli-derived compound sold for "estrogen balance" on largely preclinical grounds.Limited
- GlucomannanA viscous fiber that swells in the stomach; the one fiber with an approved satiety and weight claim in Europe.Moderate
- Green tea extractConcentrated tea catechins with a small fat-oxidation effect and a documented liver risk at high extract doses.Limited
- Myo-inositolSugar alcohol studied mainly in PCOS for insulin sensitivity and cycle regularity.Moderate
- NattokinaseAn enzyme from fermented soy with clot-dissolving activity in the lab and modest blood pressure trials in people.Limited
- Niacin (B3)Moves lipid numbers convincingly and failed to move outcomes, the clearest surrogate-endpoint lesson in this catalog.Moderate
- Plant sterolsPlant compounds that block cholesterol absorption, with one of the most consistent LDL effects in nutrition.Strong
- Red yeast riceFermented rice that naturally contains lovastatin, which is why it lowers LDL and why it carries statin risks.Moderate
- Soluble fibreBlunts glucose response and adds satiety, the least glamorous, best-supported intervention here.Strong
- YohimbineA stimulant alpha-2 blocker with a real but narrow fat-loss and erectile-function record and a rough side-effect profile.Limited
Longevity
The long-horizon bets. Evidence is thinnest here.
- AstaxanthinThe carotenoid that makes salmon pink, sold for skin and endurance on early evidence.Limited
- Calcium D-glucarateA glucaric acid salt sold for estrogen and toxin clearance, a mechanism shown in rodents only.Anecdotal
- CoQ10Mitochondrial cofactor, best studied in statin users and heart failure.Moderate
- FisetinA strawberry flavonoid with striking mouse data and, so far, almost no human data.Limited
- GlutathioneThe body's master antioxidant, heavily marketed injectable and oral, with an absorption story more complicated than the labels admit.Limited
- Lutein & zeaxanthinEye-health carotenoids with a rare distinction in this aisle: a large, well-run trial behind them.Moderate
- Methylene blueA century-old dye and medication now promoted as a nootropic and mitochondrial aid.Anecdotal
- Milk thistleThe default "liver supplement", with a trial record far more ambiguous than its reputation.Limited
- NMN / NRNAD+ precursors sold on a very large promise built on a very small human base.Limited
- PQQA vitamin-like compound sold for mitochondrial growth, a claim built on rodent studies.Limited
- PregnenoloneA steroid precursor sold for memory and mood, with old, small studies and real hormonal effects.Anecdotal
- QuercetinA common plant flavonoid, popular first for immunity and now as half of a senolytic pair.Limited
- Reishi & cordycepsThe functional-mushroom aisle beyond lion's mane, long traditional use, thin modern trials.Limited
- ResveratrolThe molecule that launched the longevity supplement industry, and the one whose original science was retracted.Limited
- SpermidineAn autophagy-inducing polyamine found in wheat germ and aged cheese, with early human work.Limited
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