Creatine Monohydrate
Muscle-preservation insurance during GLP-1-driven weight loss.
What it is
The most-studied performance/muscle supplement on the market. Increases ATP availability for short-burst work; pulls water into muscle cells (mild bloat); modestly reduces muscle catabolism during deficits.
Why peptide users take it
GLP-1 weight loss is ~25% lean mass without intervention — that's not just fat. Creatine + resistance training is the most evidence-backed defense against muscle loss during a deficit. Especially important for older users on tirzepatide/retatrutide.
Pairs with these peptides
How it actually works
Dose
When to take
Signs you actually need this
Signs it's working
Common mistakes
Where to buy
- Thorne — Creatine 16 oz powder
- Bulk Supplements — Pure Micronized Creatine
Caveats
- Causes 1–3 lb water-weight gain in week 1. Don't panic — that's intramuscular.
- Stay extra hydrated; creatine pulls water into cells.
Unlock the rest on this peptide
Members get the full mechanism, dose protocols, side effects, contraindications, common mistakes, drug interactions, and the Pepdex hot take — on every entry.
- ✓ Mechanism
- ✓ Dose protocols
- ✓ Side effects
- ✓ Drug interactions
- ✓ Common mistakes
- ✓ The Pepdex take
- ✓ Members-only Sources page — community-curated reference for research-grade material
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