pepdex
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№ 009

Semaglutide

GLP-1 agonist. The original wave. Sold as Ozempic / Wegovy.

Fat Loss
Half-life
~7 days
Route
Subcutaneous
Cycle
Open-ended, titrate over months
Schedule
Once weekly
In plain English

Semaglutide is the first wave of modern weight-loss drugs — sold as Ozempic and Wegovy. Single-receptor version of Tirzepatide. Slightly less effective and slightly rougher side effects, but well-studied and widely available.

Status & legality
Natty?
Not natty
FDA
Approved

Approved as Ozempic (2017, type 2 diabetes), Rybelsus (2019, oral), and Wegovy (2021, obesity).

WADA
Not listed
Prescribed

Yes — extremely widely prescribed. Insurance coverage variable for weight-loss indication.

Who it's for

  • →Beginners to GLP-class peptides
  • →Users with insurance coverage on Wegovy / Ozempic
  • →Metabolic-syndrome adults under provider guidance

What to expect

  1. Week 1

    Appetite drops. Nausea variable.

  2. Week 4

    First titration. 2-4lb down typically.

  3. Week 8

    5-8lb cumulative for most.

Dosing protocol

Start 0.25mg weekly. Titrate every 4 weeks. Common max 2.4mg.

Stacks well with

Standalone

Side effects

01Nausea (often more than tirzepatide)
02Constipation
03Fatigue
04Sulfur burps

When NOT to use

  • ⚠MTC / MEN-2 history
  • ⚠Pancreatitis history
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • Lipid panel
  • • ALT/AST
  • • A1C

Common mistakes

  • • Titrating too fast
  • • Skipping protein and lifting
  • • Treating it as a forever drug with no plan

Educational only. User-specific dosing is between you and a qualified provider.

Frequently asked

What is Semaglutide?+
Semaglutide is the first wave of modern weight-loss drugs — sold as Ozempic and Wegovy. Single-receptor version of Tirzepatide. Slightly less effective and slightly rougher side effects, but well-studied and widely available.
Is Semaglutide FDA approved?+
Approved as Ozempic (2017, type 2 diabetes), Rybelsus (2019, oral), and Wegovy (2021, obesity).
Is Semaglutide banned by WADA?+
Semaglutide is not currently on the WADA prohibited list.
Are you still natty after taking Semaglutide?+
No. Semaglutide is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe Semaglutide?+
Yes — extremely widely prescribed. Insurance coverage variable for weight-loss indication.
What's the typical dose of Semaglutide?+
Start 0.25mg weekly. Titrate every 4 weeks. Common max 2.4mg.
What are the side effects of Semaglutide?+
Common side effects include: Nausea (often more than tirzepatide); Constipation; Fatigue; Sulfur burps. Less common effects and full safety details are on the entry page.
How long until Semaglutide starts working?+
Appetite drops. Nausea variable.