Pepdexpepdex
My Stack
№ 022

Cagrilintide

An appetite-control shot for weight loss. A long-acting amylin agonist that works on a different pathway than the GLP-1 drugs, often paired with Semaglutide as 'CagriSema' to break GLP-1 plateaus.

Fat Loss
Evidence: Moderate

Cagrilintide: An appetite-control shot for weight loss. A long-acting amylin agonist that works on a different pathway than the GLP-1 drugs, often paired with Semaglutide as 'CagriSema' to break GLP-1 plateaus. Cagrilintide is an amylin agonist, a different appetite-control pathway than the GLP-1 drugs.

FDA ⓘ
Not approved
WADA
Not banned
Typical dose
Start 0.3 mg sub-q weekly
Half-life ⓘ
~7 days
Route ⓘ
Subcutaneous
Schedule
Once weekly
In plain English

Cagrilintide is an amylin agonist, a different appetite-control pathway than the GLP-1 drugs. Often paired with Semaglutide as 'CagriSema' for weight loss that breaks past GLP-1 plateaus. Once-weekly injection.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Investigational. Phase 3 trials by Novo Nordisk, often paired with semaglutide as 'CagriSema'.

Compounding ⓘ
Investigational

In clinical trials, not yet approved for prescription.

WADA ⓘ
Not listed
Prescribed ⓘ

Not yet approved. Trial access only.

Who it's for

  • →Users plateaued on Semaglutide or Tirzepatide
  • →People wanting cleaner satiety without bigger GLP-1 nausea
  • →Combination-therapy stacks under provider guidance

What to expect

  1. Week 1

    Mild appetite drop. Less nausea than the GLP-1 drugs.

  2. Week 4

    First titration step. Modest weight loss alone, stronger when stacked with semaglutide.

  3. Week 8

    Steady-state. Best results in 'CagriSema' combination with semaglutide.

Looking at Cagrilintide? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for Cagrilintide.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

    A free account saves your stack; membership adds the stack-aware AI Coach.

    Create free account →

How it works (mechanism)

Long-acting amylin agonist. Binds amylin receptors (also calcitonin receptor crosstalk) to slow gastric emptying and increase satiety through a different pathway than GLP-1. Pairs naturally with Semaglutide as 'CagriSema.'

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Mild nausea
02Reduced appetite
03Constipation
04Fatigue

When NOT to use

  • ⚠History of medullary thyroid carcinoma or MEN-2
  • ⚠Pancreatitis history
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • A1C if metabolic context
  • • Lipid panel

Common mistakes

  • • Expecting standalone results to match Tirzepatide (it won't)
  • • Titrating too fast
  • • Skipping protein during the cut

Drug & supplement interactions

  • ⚠Slows gastric emptying, affects oral medication absorption
  • ⚠Pairs intentionally with Semaglutide; combined nausea profile

Community patterns

Members only
Free, no account needed

New to Cagrilintide? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if Cagrilintide changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about Cagrilintide or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

Get the Coach, $7.99/mo →

Frequently asked

What is Cagrilintide?+
Cagrilintide is an amylin agonist, a different appetite-control pathway than the GLP-1 drugs. Often paired with Semaglutide as 'CagriSema' for weight loss that breaks past GLP-1 plateaus. Once-weekly injection.
Is Cagrilintide FDA approved?+
Investigational. Phase 3 trials by Novo Nordisk, often paired with semaglutide as 'CagriSema'.
Is Cagrilintide legal?+
Cagrilintide is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is Cagrilintide banned by WADA?+
Cagrilintide is not currently on the WADA prohibited list.
Are you still natty after taking Cagrilintide?+
No. Cagrilintide is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe Cagrilintide?+
Not yet approved. Trial access only.
What's the typical dose of Cagrilintide?+
Start 0.3 mg sub-q weekly. Titrate to 2.4 mg over 4-week steps. Common max 2.4 mg.
What are the side effects of Cagrilintide?+
Common side effects include: Mild nausea; Reduced appetite; Constipation; Fatigue. Less common effects and full safety details are on the entry page.
How long until Cagrilintide starts working?+
Mild appetite drop. Less nausea than the GLP-1 drugs.
What can you stack with Cagrilintide?+
Common pairings: Semaglutide (the canonical 'CagriSema' combination); Standalone for amylin-only effect. Full stacking protocol and timing on the entry page.
Where do people get Cagrilintide?+
Cagrilintide is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.
Cagrilintide vs Semaglutide, which is better?+
Semaglutide vs Cagrilintide: different appetite pathways and why CagriSema (the combo) is being studied. Full head-to-head comparison: https://pepdex.co/compare/semaglutide-vs-cagrilintide
Cagrilintide vs Tirzepatide, which is better?+
Tirzepatide vs Cagrilintide: GLP-1 + GIP appetite control vs amylin pathway. Two different levers on hunger. Full head-to-head comparison: https://pepdex.co/compare/tirzepatide-vs-cagrilintide

Head-to-head with Cagrilintide

Compare
Cagrilintide vs Semaglutide →
Compare
Cagrilintide vs Tirzepatide →

More in Fat Loss

№ 008
Tirzepatide

Strong weight loss with a cleaner side effect profile than semaglutide. A dual agonist (GLP-1 + GIP), FDA-approved as Mounjaro / Zepbound.

№ 009
Semaglutide

The original weight-loss wave, sold as Ozempic / Wegovy. A GLP-1 agonist.

№ 003
Retatrutide

Triple agonist (GLP-1 + GIP + glucagon) from Eli Lilly. In trials it outperforms Tirzepatide for weight loss.

№ 058
Liraglutide (Saxenda / Victoza)

Daily GLP-1 receptor agonist. FDA-approved 2010 (Victoza, T2D) and 2014 (Saxenda, obesity). The first wave of modern GLP-1 weight-loss therapy and direct predecessor to Semaglutide.