What are the side effects of Semaglutide?
The most commonly reported Semaglutide side effects are nausea (often more than tirzepatide), constipation, fatigue. Most are mild and tend to be dose dependent. It is generally avoided with mTC / MEN-2 history. Human clinical evidence for Semaglutide is limited, so this reflects reported and observed effects, not a complete safety profile.
Reported Semaglutide side effects
- Nausea (often more than tirzepatide)
- Constipation
- Fatigue
- Sulfur burps
Who should avoid it
- MTC / MEN-2 history
- Pancreatitis history
- Pregnancy / nursing
Bloodwork worth tracking
- Lipid panel
- ALT/AST
- A1C
References
- Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP-1) — Wilding JPH et al., NEJM, 2021
- Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT) — Lincoff et al., N Engl J Med, 2023
- Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6) — Marso et al., N Engl J Med, 2016
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.