What is the half-life of Semaglutide?
Semaglutide has a reported half life of ~7 days, given subcutaneous. That is why it is typically dosed once weekly. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~7 days
- Route: Subcutaneous
- Typical schedule: Once weekly
- Cycle length: Open-ended, titrate over months
References
- Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP-1) — Wilding JPH et al., NEJM, 2021
- Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT) — Lincoff et al., N Engl J Med, 2023
- Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6) — Marso et al., N Engl J Med, 2016
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Last updated 2026-06-15.