TUDCA (Tauroursodeoxycholic Acid)
Liver and bile-flow support — relevant if stacking peptides with anything orally hepatotoxic.
What it is
Bile acid derivative. Improves bile flow, reduces ER stress in liver cells, and shows hepatoprotective effects in clinical trials. Originally a hepatology drug; now sold as a supplement.
Why peptide users take it
Most peptides aren't hepatotoxic on their own (injection, no first-pass), but users frequently stack with orals (MK-677, anastrozole, oral AAS) where liver support genuinely matters. Also relevant for GLP-1 users with pre-existing fatty liver — some evidence of benefit.
Pairs with these peptides
How it actually works
Dose
When to take
Signs you actually need this
Signs it's working
Common mistakes
Where to buy
Editorial picks. Brand selection follows the quality criteria (USP/NSF or third-party COA where possible). Affiliate links — see the disclosure at the bottom of /supplements.
Caveats
- Diarrhea is the most common side effect; start at 250 mg.
- If you have gallstones or biliary obstruction, talk to a doctor — TUDCA increases bile flow.
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