Resveratrol
Polyphenol from red wine that activates sirtuins. The molecule that launched the modern longevity supplement industry. Bioavailability is the catch.
What it actually is
Not a peptide. Resveratrol is a stilbenoid polyphenol found in grape skins, red wine, peanuts, and Japanese knotweed. It's the molecule David Sinclair built his early longevity work around. The bioavailability problem is real — oral absorption is famously poor.
Why peptide users come across it
Often paired with NMN in 'longevity stacks' as a sirtuin activator. The whole 'NAD+ + sirtuin substrate' pairing is the dominant longevity-supplement combination. Fat-soluble — needs fat for any meaningful absorption.
Mechanism
Documented dose range
Side effects
Contraindications
The Pepdex take
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