Quercetin
Flavonoid antioxidant. Co-senolytic with fisetin or dasatinib. Anti-allergic and anti-viral support, popular as a daily polyphenol.
What it actually is
Not a peptide. Quercetin is a flavonol polyphenol found in onions, apples, capers, and berries. Acts as a potent antioxidant, mast-cell stabilizer, and (paired with dasatinib) as a senolytic. Sold heavily during COVID for the anti-viral angle.
Why peptide users come across it
The 'D+Q' senolytic protocol (dasatinib + quercetin) is the most-cited senolytic combination in the longevity literature. Daily low-dose use is common for histamine modulation, allergies, and immune support.
Mechanism
Inhibits anti-apoptotic proteins (Bcl-xL family) in senescent cells. Stabilizes mast cells (anti-allergic). Modulates NF-kB inflammatory pathway. Functions as a zinc ionophore, relevant to anti-viral protocols.
Documented dose range
Side effects
- Mild headache
- Tingling at high doses
- Possible kidney irritation in long term high-dose use
- Yellow staining of urine (harmless, indicates absorption)
Contraindications
- Active anticoagulant therapy (interacts with warfarin)
- CYP450 substrate medications (quercetin inhibits some isoforms)
- Severe kidney disease
The Pepdex take
Phytosome forms (Quercefit) have 20x bioavailability over plain quercetin dihydrate, pay the premium if you actually want it to work. Take with bromelain or vitamin C if using cheap form. Heavy interactions with cytochrome P450, check your other medications before stacking.
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