Nicotinamide Riboside (NR)
Another NAD+ precursor. ChromaDex's branded form (Niagen) is the most-studied. Competes with NMN for the 'oral path to NAD+' market.
What it actually is
Not a peptide. NR is a form of vitamin B3 — a pyridine nucleoside that serves as a substrate for NAD+ biosynthesis via the salvage pathway. One enzyme step (NRK1/2) converts NR to NMN, then on to NAD+. Patent and IP differences from NMN drive the dueling supplement market.
Why peptide users come across it
Direct competitor to NMN in the longevity supplement market. NR has more clinical trial data than NMN (ChromaDex funded extensive human studies). Both raise NAD+ — partisans argue about which is more efficient.
Mechanism
Documented dose range
Side effects
Contraindications
The Pepdex take
Unlock the rest on Nicotinamide Riboside (NR)
Members get the full mechanism, dose protocols, side effects, contraindications, common mistakes, drug interactions, and the Pepdex hot take — on every one of the 65 entries.
- ✓ Mechanism
- ✓ Dose protocols
- ✓ Side effects
- ✓ Drug interactions
- ✓ Common mistakes
- ✓ The Pepdex take
Cancel anytime · or save with $80/yr · AI Coach + Personal Stack included