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№ 065

Amycretin

Novo Nordisk's single-molecule GLP-1 + amylin co-agonist. Phase 1/2 in oral and subcutaneous formulations. The pharmacological consolidation of the Semaglutide + Cagrilintide concept into one peptide.

Fat Loss
Evidence: Moderate

Amycretin: Novo Nordisk's single-molecule GLP-1 + amylin co-agonist. Phase 1/2 in oral and subcutaneous formulations. The pharmacological consolidation of the Semaglutide + Cagrilintide concept into one peptide. Amycretin is Novo Nordisk's experiment in putting Semaglutide and Cagrilintide together as one molecule instead of two separate drugs.

FDA ⓘ
Not approved
WADA
Not banned
Typical dose
Trial doses still being established
Half-life ⓘ
~5-7 days (sub-q form)
Route ⓘ
Subcutaneous (sub-q form) or oral (oral form)
Schedule
Once weekly (sub-q) or once daily (oral)
In plain English

Amycretin is Novo Nordisk's experiment in putting Semaglutide and Cagrilintide together as one molecule instead of two separate drugs. Activates GLP-1 + amylin in a single injection. They're testing both an oral pill and a weekly injection. Phase 1/2 only, not available yet.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Investigational. Phase 1/2 trials by Novo Nordisk in oral and subcutaneous formulations.

Compounding ⓘ
Investigational

In clinical trials, not yet approved for prescription.

WADA ⓘ
Not listed
Prescribed ⓘ

Trial access only.

Who it's for

  • →Trial participants in obesity studies
  • →Followers of Novo's next-generation pipeline
  • →Educational reference for dual co-agonist design

What to expect

  1. Week 1

    Appetite drops. Some early-trial users reported faster onset than Semaglutide alone.

  2. Week 4

    First titration step.

  3. Week 8

    Phase 1b data showed weight loss outperforming Semaglutide-monotherapy comparators.

Looking at Amycretin? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for Amycretin.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

Single-molecule co-agonist, activates GLP-1 AND amylin receptors simultaneously. Pharmacological consolidation of the CagriSema concept into one peptide instead of two.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Nausea (less than Semaglutide monotherapy in early data)
02Reduced appetite
03Constipation

When NOT to use

  • ⚠MTC / MEN-2 history
  • ⚠Pancreatitis history
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • Lipid panel
  • • A1C
  • • ALT/AST

Common mistakes

  • • Expecting trial-grade material from community vendors
  • • Treating it as available-now (Phase 1/2 still)
  • • Comparing oral form dosing to sub-q form dosing

Drug & supplement interactions

  • ⚠Combined GLP-1 + amylin warnings: insulin dose reduction; slowed oral absorption
  • ⚠Trial-only, full interaction profile not yet published
Free, no account needed

New to Amycretin? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if Amycretin changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about Amycretin or your own stack. This is it working.

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Frequently asked

What is Amycretin?+
Amycretin is Novo Nordisk's experiment in putting Semaglutide and Cagrilintide together as one molecule instead of two separate drugs. Activates GLP-1 + amylin in a single injection. They're testing both an oral pill and a weekly injection. Phase 1/2 only, not available yet.
Is Amycretin FDA approved?+
Investigational. Phase 1/2 trials by Novo Nordisk in oral and subcutaneous formulations.
Is Amycretin legal?+
Amycretin is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is Amycretin banned by WADA?+
Amycretin is not currently on the WADA prohibited list.
Are you still natty after taking Amycretin?+
No. Amycretin is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe Amycretin?+
Trial access only.
What's the typical dose of Amycretin?+
Trial doses still being established. Sub-q forms tested up to 60 mg weekly (Lancet phase 1b/2a, ~24% weight loss at 36 weeks).
What are the side effects of Amycretin?+
Common side effects include: Nausea (less than Semaglutide monotherapy in early data); Reduced appetite; Constipation. Less common effects and full safety details are on the entry page.
How long until Amycretin starts working?+
Appetite drops. Some early-trial users reported faster onset than Semaglutide alone.
What can you stack with Amycretin?+
Common pairings: Standalone, this IS the dual stack in one molecule. Full stacking protocol and timing on the entry page.
Where do people get Amycretin?+
Amycretin is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.

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Tirzepatide

Strong weight loss with a cleaner side effect profile than semaglutide. A dual agonist (GLP-1 + GIP), FDA-approved as Mounjaro / Zepbound.

№ 009
Semaglutide

The original weight-loss wave, sold as Ozempic / Wegovy. A GLP-1 agonist.

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Retatrutide

Triple agonist (GLP-1 + GIP + glucagon) from Eli Lilly. In trials it outperforms Tirzepatide for weight loss.

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Liraglutide (Saxenda / Victoza)

Daily GLP-1 receptor agonist. FDA-approved 2010 (Victoza, T2D) and 2014 (Saxenda, obesity). The first wave of modern GLP-1 weight-loss therapy and direct predecessor to Semaglutide.