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№ 064

Pemvidutide

Altimmune's GLP-1 + glucagon dual agonist. Phase 2 data shows weight loss alongside meaningful liver-fat reduction (NASH/MASH applications). Direct competitor to Retatrutide and Survodutide.

Fat Loss
Evidence: Moderate

Pemvidutide: Altimmune's GLP-1 + glucagon dual agonist. Phase 2 data shows weight loss alongside meaningful liver-fat reduction (NASH/MASH applications). Direct competitor to Retatrutide and Survodutide. Pemvidutide is Altimmune's competitor to Retatrutide and Survodutide, a GLP-1 + glucagon dual agonist.

FDA ⓘ
Not approved
WADA
Not banned
Typical dose
Trial doses 1.2-2.4 mg weekly
Half-life ⓘ
~5 days
Route ⓘ
Subcutaneous
Schedule
Once weekly
In plain English

Pemvidutide is Altimmune's competitor to Retatrutide and Survodutide, a GLP-1 + glucagon dual agonist. The interesting thing about Pemvidutide is it shows real liver-fat reduction in addition to weight loss, making it a NASH/MASH drug candidate too. Phase 2 in development.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Investigational. Phase 2 trials by Altimmune for obesity and NASH/MASH.

Compounding ⓘ
Investigational

In clinical trials, not yet approved for prescription.

WADA ⓘ
Not listed
Prescribed ⓘ

Trial access only.

Who it's for

  • →Trial participants in NASH/MASH or obesity studies
  • →Patients with metabolic-syndrome plus liver involvement
  • →Followers of Altimmune's pipeline

What to expect

  1. Week 1

    Appetite drops. Mild nausea. Slight body-temp uptick from glucagon arm.

  2. Week 4

    First titration step. Weight loss tracking.

  3. Week 8

    Phase 2 showed liver-fat reduction beginning to compound.

Looking at Pemvidutide? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for Pemvidutide.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

GLP-1 + glucagon dual agonist with structural design favoring liver-fat reduction alongside weight loss, making it a NASH/MASH candidate as well as obesity.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Nausea (titration steps)
02Diarrhea
03Mild HR increase (glucagon effect)
04Fatigue

When NOT to use

  • ⚠MTC / MEN-2 history
  • ⚠Pancreatitis history
  • ⚠Severe cardiovascular disease
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • Lipid panel
  • • ALT/AST
  • • Liver imaging if NASH context
  • • A1C

Common mistakes

  • • Treating elevated HR as caffeine sensitivity
  • • Titrating too fast
  • • Not getting baseline liver imaging if NASH-related

Drug & supplement interactions

  • ⚠Same GLP/glucagon class warnings
  • ⚠Trial-only, full interaction profile not yet published

Community patterns

Members only
Free, no account needed

New to Pemvidutide? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if Pemvidutide changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about Pemvidutide or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

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Frequently asked

What is Pemvidutide?+
Pemvidutide is Altimmune's competitor to Retatrutide and Survodutide, a GLP-1 + glucagon dual agonist. The interesting thing about Pemvidutide is it shows real liver-fat reduction in addition to weight loss, making it a NASH/MASH drug candidate too. Phase 2 in development.
Is Pemvidutide FDA approved?+
Investigational. Phase 2 trials by Altimmune for obesity and NASH/MASH.
Is Pemvidutide legal?+
Pemvidutide is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is Pemvidutide banned by WADA?+
Pemvidutide is not currently on the WADA prohibited list.
Are you still natty after taking Pemvidutide?+
No. Pemvidutide is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe Pemvidutide?+
Trial access only.
What's the typical dose of Pemvidutide?+
Trial doses 1.2-2.4 mg weekly. Titrate over 4-week steps.
What are the side effects of Pemvidutide?+
Common side effects include: Nausea (titration steps); Diarrhea; Mild HR increase (glucagon effect); Fatigue. Less common effects and full safety details are on the entry page.
How long until Pemvidutide starts working?+
Appetite drops. Mild nausea. Slight body-temp uptick from glucagon arm.
What can you stack with Pemvidutide?+
Common pairings: Standalone in current trials. Full stacking protocol and timing on the entry page.
Where do people get Pemvidutide?+
Pemvidutide is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.

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Semaglutide

The original weight-loss wave, sold as Ozempic / Wegovy. A GLP-1 agonist.

№ 003
Retatrutide

Triple agonist (GLP-1 + GIP + glucagon) from Eli Lilly. In trials it outperforms Tirzepatide for weight loss.

№ 058
Liraglutide (Saxenda / Victoza)

Daily GLP-1 receptor agonist. FDA-approved 2010 (Victoza, T2D) and 2014 (Saxenda, obesity). The first wave of modern GLP-1 weight-loss therapy and direct predecessor to Semaglutide.