Pepdexpepdex
My Stack
№ 040

ARA-290 (Cibinetide)

A compound studied for calming nerve pain and inflammation without raising red blood cells. An EPO-derived peptide that targets the innate-repair receptor without the red-blood-cell side of erythropoietin, studied for neuropathic pain, sarcoidosis, and diabetic complications.

Healing
Evidence: Moderate

ARA-290 (Cibinetide): A compound studied for calming nerve pain and inflammation without raising red blood cells. An EPO-derived peptide that targets the innate-repair receptor without the red-blood-cell side of erythropoietin, studied for neuropathic pain, sarcoidosis, and diabetic complications. ARA-290 is derived from EPO (erythropoietin) but doesn't bump red blood cells the way EPO does.

FDA ⓘ
Not approved
WADA
Not banned
Typical dose
2-4 mg sub-q daily.
Half-life ⓘ
~20 min terminal (subcutaneous; ~2 min IV)
Route ⓘ
Subcutaneous
Schedule
Once daily
In plain English

ARA-290 is derived from EPO (erythropoietin) but doesn't bump red blood cells the way EPO does. It targets the innate-repair receptor instead. Real Phase 2 data for neuropathic pain and sarcoidosis. Useful for chronic nerve issues.

Status & legalityWhat do these mean? →
Natty? ⓘ
Grey area
FDA ⓘ
Not approved

Investigational. Phase 2 trials in sarcoidosis and diabetic neuropathy.

Compounding ⓘ
Investigational

In clinical trials, not yet approved for prescription.

WADA ⓘ
Not listed

Doesn't trigger erythropoiesis like EPO does, but interpretation varies.

Prescribed ⓘ

Not commercially available.

Who it's for

  • →Users with neuropathic pain (small-fiber neuropathy)
  • →Sarcoidosis patients (Phase 2 data)
  • →Healing stacks for nerve-involved injuries

What to expect

  1. Week 1

    Subtle. Some neuropathic pain users notice first nerve-tingling reduction.

  2. Week 4

    Cumulative effect. Sarcoidosis trial endpoint.

  3. Week 8

    Sustained users see compounding benefits.

Looking at ARA-290 (Cibinetide)? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for ARA-290 (Cibinetide).

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

    A free account saves your stack; membership adds the stack-aware AI Coach.

    Create free account →

How it works (mechanism)

Erythropoietin-derived peptide that activates the innate-repair receptor (heteromer of EPO-R and CD131) without triggering erythropoiesis. Reduces inflammation and supports nerve and tissue healing without raising red blood cells.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Generally well tolerated
02Rare: mild headache
03Injection-site reaction

When NOT to use

  • ⚠Pregnancy / nursing
  • ⚠Active malignancy, limited data

Bloodwork to monitor

  • • CBC (no measurable RBC effect, but cheap monitoring if running long)

Common mistakes

  • • Expecting fast pain relief (cumulative over weeks)
  • • Stopping too early
  • • Underdosing, 1 mg often produces no measurable change

Drug & supplement interactions

  • ⚠Limited documented interactions
  • ⚠Doesn't trigger erythropoiesis like EPO does, less interaction with iron / hematinic agents
Free, no account needed

New to ARA-290 (Cibinetide)? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if ARA-290 (Cibinetide) changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about ARA-290 (Cibinetide) or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

Get the Coach, $7.99/mo →

Frequently asked

What is ARA-290 (Cibinetide)?+
ARA-290 is derived from EPO (erythropoietin) but doesn't bump red blood cells the way EPO does. It targets the innate-repair receptor instead. Real Phase 2 data for neuropathic pain and sarcoidosis. Useful for chronic nerve issues.
Is ARA-290 (Cibinetide) FDA approved?+
Investigational. Phase 2 trials in sarcoidosis and diabetic neuropathy.
Is ARA-290 (Cibinetide) legal?+
ARA-290 (Cibinetide) is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is ARA-290 (Cibinetide) banned by WADA?+
ARA-290 (Cibinetide) is not currently on the WADA prohibited list. Doesn't trigger erythropoiesis like EPO does, but interpretation varies.
Are you still natty after taking ARA-290 (Cibinetide)?+
Grey area. Federations differ on whether this disqualifies natty status.
Do doctors prescribe ARA-290 (Cibinetide)?+
Not commercially available.
What's the typical dose of ARA-290 (Cibinetide)?+
2-4 mg sub-q daily.
What are the side effects of ARA-290 (Cibinetide)?+
Common side effects include: Generally well tolerated; Rare: mild headache; Injection-site reaction. Less common effects and full safety details are on the entry page.
How long until ARA-290 (Cibinetide) starts working?+
Subtle. Some neuropathic pain users notice first nerve-tingling reduction.
What can you stack with ARA-290 (Cibinetide)?+
Common pairings: BPC-157 + TB-500 for nerve+tissue healing protocols; Standalone for neuropathic pain. Full stacking protocol and timing on the entry page.
Where do people get ARA-290 (Cibinetide)?+
ARA-290 (Cibinetide) is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.

More in Healing

№ 001
BPC-157

Synthetic peptide derived from a stomach protein. Used to speed up tendon, ligament, and gut healing.

№ 002
TB-500

A fragment of Thymosin Beta-4. Drives cell migration and tissue repair, used for chronic soft-tissue stuff.

№ 042
Teriparatide

A bone-building drug. A parathyroid-hormone fragment (PTH 1-34), FDA-approved as Forteo for severe osteoporosis. Anabolic for bone, the opposite of bisphosphonates.

№ 062
Teduglutide (Gattex / Revestive)

A gut drug that helps people with short bowel syndrome absorb more nutrients. A recombinant GLP-2 analog, FDA-approved in 2012 for short bowel syndrome with intestinal failure; it hits a different receptor and indication than the GLP-1 weight-loss drugs.