ARA-290 (Cibinetide)
EPO-derived peptide that targets the innate-repair receptor without the red-blood-cell side of erythropoietin. Studied for neuropathic pain, sarcoidosis, diabetic complications.
ARA-290 is derived from EPO (erythropoietin) but doesn't bump red blood cells the way EPO does. It targets the innate-repair receptor instead. Real Phase 2 data for neuropathic pain and sarcoidosis. Useful for chronic nerve issues.
Investigational. Phase 2 trials in sarcoidosis and diabetic neuropathy.
In clinical trials, not yet approved for prescription.
Doesn't trigger erythropoiesis like EPO does, but interpretation varies.
Not commercially available.
Who it's for
- →Users with neuropathic pain (small-fiber neuropathy)
- →Sarcoidosis patients (Phase 2 data)
- →Healing stacks for nerve-involved injuries
What to expect
- Week 1
Subtle. Some neuropathic pain users notice first nerve-tingling reduction.
- Week 4
Cumulative effect. Sarcoidosis trial endpoint.
- Week 8
Sustained users see compounding benefits.
How it works (mechanism)
Erythropoietin-derived peptide that activates the innate-repair receptor (heteromer of EPO-R and CD131) without triggering erythropoiesis. Reduces inflammation and supports nerve and tissue healing without raising red blood cells.
Dosing protocol
2-4 mg sub-q daily.
Stacks well with
Side effects
When NOT to use
- ⚠Pregnancy / nursing
- ⚠Active malignancy — limited data
Bloodwork to monitor
- • CBC (no measurable RBC effect, but cheap monitoring if running long)
Common mistakes
- • Expecting fast pain relief (cumulative over weeks)
- • Stopping too early
- • Underdosing — 1 mg often produces no measurable change
Drug & supplement interactions
- ⚠Limited documented interactions
- ⚠Doesn't trigger erythropoiesis like EPO does — less interaction with iron / hematinic agents
Educational only. User-specific dosing is between you and a qualified provider.
Frequently asked
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