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№ 002

TB-500

A fragment of Thymosin Beta-4. Drives cell migration and tissue repair, used for chronic soft-tissue stuff.

Healing
Evidence: Limited

TB-500: A fragment of Thymosin Beta-4. Drives cell migration and tissue repair, used for chronic soft-tissue stuff. TB-500 is a fragment of a natural healing protein your body already makes.

FDA ⓘ
Not approved
WADA
Banned
Typical dose
Loading: 2-2.5mg twice weekly for 4-6 weeks
Half-life ⓘ
~2-3 days
Route ⓘ
Subcutaneous or intramuscular
Schedule
Loading 2x/wk → maintenance 1x/wk
In plain English

TB-500 is a fragment of a natural healing protein your body already makes. It's used for chronic injuries that won't resolve on their own, old shoulder issues, lingering tendon pain. You usually pair it with BPC-157 for a stronger combined effect.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Not FDA approved for any indication.

Compounding ⓘ
Category 1

Compounding pharmacies may prepare under physician prescription (post Feb 2026 reclassification, pending formal FDA publication).

WADA ⓘ
Banned (S2)
Prescribed ⓘ

Not prescribed in conventional medicine.

Who it's for

  • →Anyone with a chronic soft-tissue injury that won't resolve
  • →Lifters running BPC-157 for synergy
  • →Athletes in connective-tissue recovery phases

What to expect

  1. Week 1

    Mild fatigue first few days from the loading phase.

  2. Week 4

    Loading phase ends. Most users feel the underlying injury settling.

  3. Week 8

    Maintenance phase. Cumulative effect on chronic tissue.

Looking at TB-500? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for TB-500.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

Active fragment of Thymosin Beta-4 that binds and sequesters G-actin, accelerating cell migration to wound sites. Promotes endothelial migration, capillary formation, and tissue repair across multiple organs.

Dosing protocol

Members only

Stacks well with

Members only

Stack essentials

Members only

Side effects

01Mild fatigue during loading
02Injection-site soreness
03Brief head-rush at injection

When NOT to use

  • ⚠Active malignancy
  • ⚠Pregnancy / nursing (no data)

Common mistakes

  • • Skipping the loading phase, then wondering why nothing happened
  • • Stopping at 4 weeks instead of completing the full cycle
  • • Storing reconstituted vials at room temp instead of refrigerated

Drug & supplement interactions

  • ⚠Limited documented drug interactions
  • ⚠Theoretical caution with pro-angiogenic compounds in malignancy contexts

Community patterns

Members only
Free, no account needed

New to TB-500? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if TB-500 changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about TB-500 or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

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Frequently asked

What is TB-500?+
TB-500 is a fragment of a natural healing protein your body already makes. It's used for chronic injuries that won't resolve on their own, old shoulder issues, lingering tendon pain. You usually pair it with BPC-157 for a stronger combined effect.
Is TB-500 FDA approved?+
Not FDA approved for any indication.
Is TB-500 legal?+
TB-500 is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is TB-500 banned by WADA?+
TB-500 is on the WADA prohibited list under Banned (S2).
Are you still natty after taking TB-500?+
No. TB-500 is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe TB-500?+
Not prescribed in conventional medicine.
What's the typical dose of TB-500?+
Loading: 2-2.5mg twice weekly for 4-6 weeks. Maintenance: 2-2.5mg weekly for 4-8 weeks.
What are the side effects of TB-500?+
Common side effects include: Mild fatigue during loading; Injection-site soreness; Brief head-rush at injection. Less common effects and full safety details are on the entry page.
How long until TB-500 starts working?+
Mild fatigue first few days from the loading phase.
What can you stack with TB-500?+
Common pairings: BPC-157 (the canonical healing stack). Full stacking protocol and timing on the entry page.
Where do people get TB-500?+
TB-500 is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.
TB-500 vs BPC-157, which is better?+
BPC-157 vs TB-500 for healing: which to pick, and why most users run them together as the canonical healing stack. Full head-to-head comparison: https://pepdex.co/compare/bpc-157-vs-tb-500
TB-500 vs GHK-Cu, which is better?+
TB-500 vs GHK-Cu: cell migration and tissue repair vs collagen and copper-driven healing. Full head-to-head comparison: https://pepdex.co/compare/tb-500-vs-ghk-cu

Head-to-head with TB-500

Compare
TB-500 vs BPC-157 →
Compare
TB-500 vs GHK-Cu →

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