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Comparison

TB-500 vs GHK-Cu

TB-500 vs GHK-Cu: cell migration and tissue repair vs collagen and copper-driven healing.

The verdict

Two different healing layers. TB-500 drives cell migration and systemic soft-tissue repair, it's the 'move recovery across the whole body' peptide. GHK-Cu is the copper-binding tripeptide that supports collagen, skin, and follicles, more surface-and-structure than deep tissue. For chronic soft-tissue or muscle recovery, TB-500. For skin quality, scarring, or hair, GHK-Cu. They show up together in skin-plus-healing stacks like GLOW precisely because they cover separate ground.

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TB-500
HealingEvidence: Limited

TB-500 is a fragment of a natural healing protein your body already makes. It's used for chronic injuries that won't resolve on their own, old shoulder issues, lingering tendon pain. You usually pair it with BPC-157 for a stronger combined effect.

Onset
50
Documentation
55
Side intensity
64
Popularity
70
005
GHK-Cu
SkinEvidence: Limited

GHK-Cu is a tiny copper-binding peptide your skin already has, but levels drop with age. Used to support collagen, wound healing, and hair follicles. Topical for skin, sub-q injection for systemic effect on connective tissue.

Onset
45
Documentation
50
Side intensity
64
Popularity
60
Side-by-side
Field
Left
Right
Category
Healing
Skin
Half-life
~2-3 days
~2 hours systemic
Route
Subcutaneous or intramuscular
Sub-q (systemic) or topical (skin)
Schedule
Loading 2x/wk → maintenance 1x/wk
Daily
Cycle length
8-12 weeks total
4-6 weeks
Dose
Loading: 2-2.5mg twice weekly for 4-6 weeks. Maintenance: 2-2.5mg weekly for 4-8 weeks.
Sub-q: 1-2mg daily, 4-6 week cycles. Topical: 0.05-0.2% concentration, 1-2x daily.
FDA
Not FDA approved for any indication.
Approved as a cosmetic ingredient. Not approved as a drug.
WADA
Banned (S2)
Not listed
Natty?
Not natty
Grey area
Prescribed
Not prescribed in conventional medicine.
Not prescribed; widely used as topical skincare ingredient.
Top side effects
Mild fatigue during loading; Injection-site soreness; Brief head-rush at injection
Injection-site flush; Mild metallic taste shortly after dose; Rare: headache

Which one should you pick?

Pick TB-500 if anyone with a chronic soft-tissue injury that won't resolve or lifters running bpc-157 for synergy.

Pick GHK-Cu if anyone running an aggressive skin/anti-aging routine or healing stack add-on for connective tissue.

AI Coach · free

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