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№ 062

Teduglutide (Gattex / Revestive)

A gut drug that helps people with short bowel syndrome absorb more nutrients. A recombinant GLP-2 analog, FDA-approved in 2012 for short bowel syndrome with intestinal failure; it hits a different receptor and indication than the GLP-1 weight-loss drugs.

Healing
Evidence: Strong

Teduglutide (Gattex / Revestive): A gut drug that helps people with short bowel syndrome absorb more nutrients. A recombinant GLP-2 analog, FDA-approved in 2012 for short bowel syndrome with intestinal failure; it hits a different receptor and indication than the GLP-1 weight-loss drugs. Teduglutide (sold as Gattex) is a GLP-2 drug, different family than the GLP-1 weight-loss drugs.

FDA ⓘ
Approved
WADA
Not banned
Typical dose
0.05 mg/kg sub-q daily
Half-life ⓘ
~2 hours
Route ⓘ
Subcutaneous
Schedule
Once daily
In plain English

Teduglutide (sold as Gattex) is a GLP-2 drug, different family than the GLP-1 weight-loss drugs. FDA-approved for short bowel syndrome, where patients can't absorb enough nutrients from food. Helps the remaining bowel work better. Daily injection, requires colonoscopy monitoring.

Status & legalityWhat do these mean? →
Natty? ⓘ
Considered natty

GI-recovery drug, not a performance-enhancing peptide. Federations don't typically address it.

FDA ⓘ
Approved

Approved as Gattex / Revestive (2012) for short bowel syndrome with intestinal failure.

Compounding ⓘ
Approved drug

Available as an FDA-approved drug, not a compounded peptide.

WADA ⓘ
Not listed
Prescribed ⓘ

Yes, gastroenterology specialists prescribe for short-bowel-syndrome patients.

Who it's for

  • →Short bowel syndrome patients on parenteral nutrition
  • →Intestinal-failure recovery contexts
  • →Educational reference for the GLP-2 vs GLP-1 distinction

What to expect

  1. Week 1

    Intestinal absorption markers begin shifting.

  2. Week 4

    Parenteral nutrition requirements drop in responders.

  3. Week 8

    Sustained absorption improvement.

Looking at Teduglutide (Gattex / Revestive)? Your next 3 steps

  1. 1Work out your exact dose

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  2. 2See what to stack & monitor

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How it works (mechanism)

Recombinant analog of GLP-2, a hormone that promotes intestinal epithelial growth and absorption. Different receptor than GLP-1 (different family). FDA-approved for short bowel syndrome.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Abdominal pain
02Nausea
03Fluid overload
04Polyp / neoplasia risk (intestinal; requires colonoscopy surveillance, not a boxed warning)
05Injection-site reaction

When NOT to use

  • ⚠Active or suspected GI malignancy
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • Colonoscopy at baseline + intervals
  • • ALT/AST
  • • Magnesium / electrolytes

Common mistakes

  • • Skipping the colonoscopy schedule (polyp risk is real)
  • • Confusing GLP-2 with GLP-1 (different receptor, different indication)
  • • Using it outside short-bowel indication

Drug & supplement interactions

  • ⚠Polyp surveillance required, drugs that promote epithelial growth should be reviewed with provider
  • ⚠Affects absorption of orally-dosed medications (variable per individual)
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AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

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Frequently asked

What is Teduglutide (Gattex / Revestive)?+
Teduglutide (sold as Gattex) is a GLP-2 drug, different family than the GLP-1 weight-loss drugs. FDA-approved for short bowel syndrome, where patients can't absorb enough nutrients from food. Helps the remaining bowel work better. Daily injection, requires colonoscopy monitoring.
Is Teduglutide (Gattex / Revestive) FDA approved?+
Approved as Gattex / Revestive (2012) for short bowel syndrome with intestinal failure.
Is Teduglutide (Gattex / Revestive) legal?+
Teduglutide (Gattex / Revestive) is FDA-approved and legal to obtain by prescription in the US. Yes, gastroenterology specialists prescribe for short-bowel-syndrome patients.
Is Teduglutide (Gattex / Revestive) banned by WADA?+
Teduglutide (Gattex / Revestive) is not currently on the WADA prohibited list.
Are you still natty after taking Teduglutide (Gattex / Revestive)?+
Teduglutide (Gattex / Revestive) is generally considered natty-compatible. GI-recovery drug, not a performance-enhancing peptide. Federations don't typically address it.
Do doctors prescribe Teduglutide (Gattex / Revestive)?+
Yes, gastroenterology specialists prescribe for short-bowel-syndrome patients.
What's the typical dose of Teduglutide (Gattex / Revestive)?+
0.05 mg/kg sub-q daily, rotating injection sites.
What are the side effects of Teduglutide (Gattex / Revestive)?+
Common side effects include: Abdominal pain; Nausea; Fluid overload; Polyp / neoplasia risk (intestinal; requires colonoscopy surveillance, not a boxed warning). Less common effects and full safety details are on the entry page.
How long until Teduglutide (Gattex / Revestive) starts working?+
Intestinal absorption markers begin shifting.
What can you stack with Teduglutide (Gattex / Revestive)?+
Common pairings: Standalone, paired with parenteral nutrition weaning protocol. Full stacking protocol and timing on the entry page.
Where do people get Teduglutide (Gattex / Revestive)?+
Teduglutide (Gattex / Revestive) is dispensed through licensed pharmacies with a prescription. Some compounding pharmacies and telehealth services prescribe it. Pepdex is not a vendor or pharmacy. See /coa for how to verify Certificate of Analysis on any supplier.

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