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№ 062

Teduglutide (Gattex / Revestive)

Recombinant GLP-2 analog. FDA-approved 2012 for short bowel syndrome with intestinal failure. Different receptor and indication than the GLP-1 weight-loss drugs.

Healing
Evidence: Strong
Half-life
~2 hours
Route
Subcutaneous
Cycle
Long-term in approved indication
Schedule
Once daily
In plain English

Teduglutide (sold as Gattex) is a GLP-2 drug — different family than the GLP-1 weight-loss drugs. FDA-approved for short bowel syndrome, where patients can't absorb enough nutrients from food. Helps the remaining bowel work better. Daily injection, requires colonoscopy monitoring.

Status & legality
Natty?
Considered natty

GI-recovery drug, not a performance-enhancing peptide. Federations don't typically address it.

FDA
Approved

Approved as Gattex / Revestive (2012) for short bowel syndrome with intestinal failure.

Compounding
Approved drug

Available as an FDA-approved drug, not a compounded peptide.

WADA
Not listed
Prescribed

Yes — gastroenterology specialists prescribe for short-bowel-syndrome patients.

Who it's for

  • →Short bowel syndrome patients on parenteral nutrition
  • →Intestinal-failure recovery contexts
  • →Educational reference for the GLP-2 vs GLP-1 distinction

What to expect

  1. Week 1

    Intestinal absorption markers begin shifting.

  2. Week 4

    Parenteral nutrition requirements drop in responders.

  3. Week 8

    Sustained absorption improvement.

How it works (mechanism)

Recombinant analog of GLP-2, a hormone that promotes intestinal epithelial growth and absorption. Different receptor than GLP-1 (different family). FDA-approved for short bowel syndrome.

Dosing protocol

0.05 mg/kg sub-q daily, rotating injection sites.

Stacks well with

Standalone — paired with parenteral nutrition weaning protocol

Side effects

01Abdominal pain
02Nausea
03Fluid overload
04Polyp growth (intestinal — black-box requires colonoscopy surveillance)
05Injection-site reaction

When NOT to use

  • ⚠Active or suspected GI malignancy
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • Colonoscopy at baseline + intervals
  • • ALT/AST
  • • Magnesium / electrolytes

Common mistakes

  • • Skipping the colonoscopy schedule (polyp risk is real)
  • • Confusing GLP-2 with GLP-1 (different receptor, different indication)
  • • Using it outside short-bowel indication

Drug & supplement interactions

  • ⚠Polyp surveillance required — drugs that promote epithelial growth should be reviewed with provider
  • ⚠Affects absorption of orally-dosed medications (variable per individual)

Educational only. User-specific dosing is between you and a qualified provider.

Frequently asked

What is Teduglutide (Gattex / Revestive)?+
Teduglutide (sold as Gattex) is a GLP-2 drug — different family than the GLP-1 weight-loss drugs. FDA-approved for short bowel syndrome, where patients can't absorb enough nutrients from food. Helps the remaining bowel work better. Daily injection, requires colonoscopy monitoring.
Is Teduglutide (Gattex / Revestive) FDA approved?+
Approved as Gattex / Revestive (2012) for short bowel syndrome with intestinal failure.
Is Teduglutide (Gattex / Revestive) banned by WADA?+
Teduglutide (Gattex / Revestive) is not currently on the WADA prohibited list.
Are you still natty after taking Teduglutide (Gattex / Revestive)?+
Teduglutide (Gattex / Revestive) is generally considered natty-compatible. GI-recovery drug, not a performance-enhancing peptide. Federations don't typically address it.
Do doctors prescribe Teduglutide (Gattex / Revestive)?+
Yes — gastroenterology specialists prescribe for short-bowel-syndrome patients.
What's the typical dose of Teduglutide (Gattex / Revestive)?+
0.05 mg/kg sub-q daily, rotating injection sites.
What are the side effects of Teduglutide (Gattex / Revestive)?+
Common side effects include: Abdominal pain; Nausea; Fluid overload; Polyp growth (intestinal — black-box requires colonoscopy surveillance). Less common effects and full safety details are on the entry page.
How long until Teduglutide (Gattex / Revestive) starts working?+
Intestinal absorption markers begin shifting.

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