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№ 034

Mazdutide

A weight-loss shot already approved in China. Innovent Biologics' GLP-1 + glucagon dual agonist out of China, with strong Phase 3 data and a 2025 China approval for obesity.

Fat Loss
Evidence: Moderate

Mazdutide: A weight-loss shot already approved in China. Innovent Biologics' GLP-1 + glucagon dual agonist out of China, with strong Phase 3 data and a 2025 China approval for obesity. Mazdutide is a Chinese-developed GLP-1 + glucagon dual agonist, same class as Survodutide and Retatrutide.

FDA ⓘ
Not approved
WADA
Not banned
Typical dose
Start 3 mg weekly
Half-life ⓘ
~8 days (dose-dependent)
Route ⓘ
Subcutaneous
Schedule
Once weekly
In plain English

Mazdutide is a Chinese-developed GLP-1 + glucagon dual agonist, same class as Survodutide and Retatrutide. Approved in China in 2025 for obesity. The glucagon part adds a metabolic-rate bump on top of GLP-1's appetite suppression.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Not FDA approved. Approved in China (2025, Innovent, brand Xinermei) for obesity and type 2 diabetes. Eli Lilly holds ex-China rights (LY-3305677) and runs US development (Phase 2).

Compounding ⓘ
Investigational

In clinical trials, not yet approved for prescription.

WADA ⓘ
Not listed
Prescribed ⓘ

Available by prescription in China. Not yet available in the US.

Who it's for

  • →Users wanting a GLP/glucagon agonist with cleaner side effect profile than Survodutide reports
  • →Followers of Chinese metabolic-drug development

What to expect

  1. Week 1

    Appetite drops. Mild nausea.

  2. Week 4

    First titration step. Modest weight loss.

  3. Week 8

    Cumulative loss tracking similar to Tirzepatide trajectory.

Looking at Mazdutide? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for Mazdutide.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

GLP-1 + glucagon dual agonist developed in China. Same dual-receptor strategy as Survodutide.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Nausea
02Constipation or diarrhea
03Mild fatigue
04Slightly elevated heart rate (glucagon effect)

When NOT to use

  • ⚠MTC / MEN-2 history
  • ⚠Pancreatitis history
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • Lipid panel
  • • ALT/AST
  • • A1C

Common mistakes

  • • Treating it as freely available, it's only approved in China currently
  • • Titrating too fast
  • • Skipping protein during the cut

Drug & supplement interactions

  • ⚠Insulin and sulfonylureas: dose reduction needed
  • ⚠Glucagon arm: monitor HR
  • ⚠Trial-only outside China, full US interaction profile not yet published

Community patterns

Members only
Free, no account needed

New to Mazdutide? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if Mazdutide changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about Mazdutide or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

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Frequently asked

What is Mazdutide?+
Mazdutide is a Chinese-developed GLP-1 + glucagon dual agonist, same class as Survodutide and Retatrutide. Approved in China in 2025 for obesity. The glucagon part adds a metabolic-rate bump on top of GLP-1's appetite suppression.
Is Mazdutide FDA approved?+
Not FDA approved. Approved in China (2025, Innovent, brand Xinermei) for obesity and type 2 diabetes. Eli Lilly holds ex-China rights (LY-3305677) and runs US development (Phase 2).
Is Mazdutide legal?+
Mazdutide is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is Mazdutide banned by WADA?+
Mazdutide is not currently on the WADA prohibited list.
Are you still natty after taking Mazdutide?+
No. Mazdutide is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe Mazdutide?+
Available by prescription in China. Not yet available in the US.
What's the typical dose of Mazdutide?+
Start 3 mg weekly. Titrate to 6-9 mg over 4-week steps based on tolerance.
What are the side effects of Mazdutide?+
Common side effects include: Nausea; Constipation or diarrhea; Mild fatigue; Slightly elevated heart rate (glucagon effect). Less common effects and full safety details are on the entry page.
How long until Mazdutide starts working?+
Appetite drops. Mild nausea.
What can you stack with Mazdutide?+
Common pairings: Standalone is the norm; Some users add MOTS-c during cuts. Full stacking protocol and timing on the entry page.
Where do people get Mazdutide?+
Mazdutide is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.
Mazdutide vs Survodutide, which is better?+
Mazdutide vs Survodutide: two late-stage GLP-1 + glucagon dual agonists. Innovent vs Boehringer Ingelheim development paths. Full head-to-head comparison: https://pepdex.co/compare/mazdutide-vs-survodutide
Mazdutide vs Semaglutide, which is better?+
Semaglutide vs Mazdutide: GLP-1 only vs GLP-1 + glucagon dual agonist. China-approved Mazdutide vs the global standard. Full head-to-head comparison: https://pepdex.co/compare/semaglutide-vs-mazdutide

Head-to-head with Mazdutide

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Mazdutide vs Survodutide →
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Mazdutide vs Semaglutide →

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Tirzepatide

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Triple agonist (GLP-1 + GIP + glucagon) from Eli Lilly. In trials it outperforms Tirzepatide for weight loss.

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Liraglutide (Saxenda / Victoza)

Daily GLP-1 receptor agonist. FDA-approved 2010 (Victoza, T2D) and 2014 (Saxenda, obesity). The first wave of modern GLP-1 weight-loss therapy and direct predecessor to Semaglutide.