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№ 035

SS-31 (Elamipretide / MTP-131)

Boosts your cells' energy production at the source. A mitochondria-targeting peptide that concentrates in the inner mitochondrial membrane to support ATP production, FDA-approved in 2025 as FORZINITY for Barth syndrome, the first mitochondria-targeted drug, with all other uses off-label.

Metabolic
Evidence: Moderate

SS-31 (Elamipretide / MTP-131): Boosts your cells' energy production at the source. A mitochondria-targeting peptide that concentrates in the inner mitochondrial membrane to support ATP production, FDA-approved in 2025 as FORZINITY for Barth syndrome, the first mitochondria-targeted drug, with all other uses off-label. SS-31 (also called Elamipretide or MTP-131) targets your mitochondria, the energy plants inside your cells.

FDA ⓘ
Approved
WADA
Not banned
Typical dose
5-40 mg sub-q daily
Half-life ⓘ
~2-4 hours
Route ⓘ
Subcutaneous
Schedule
Once daily
In plain English

SS-31 (also called Elamipretide or MTP-131) targets your mitochondria, the energy plants inside your cells. It concentrates in the inner mitochondrial membrane and supports ATP production. Used by people with mitochondrial-flavored fatigue and as a longevity adjunct.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Approved

FDA-approved as FORZINITY (elamipretide) on Sept 19, 2025 under accelerated approval, to improve muscle strength in adult and pediatric Barth syndrome patients weighing >=30 kg. The first FDA-approved mitochondria-targeted drug. Approved only for Barth syndrome, every other use (longevity, general mitochondrial support) is off-label and unapproved.

Compounding ⓘ
Approved drug

Available as an FDA-approved drug, not a compounded peptide.

WADA ⓘ
Not listed
Prescribed ⓘ

Yes for Barth syndrome (FORZINITY, 40 mg sub-q daily), via specialty pharmacy. Not commercially available for off-label longevity use.

Who it's for

  • →Users with mitochondrial-flavored fatigue
  • →Older adults targeting cellular bioenergetics
  • →Stack add-ons for hard-training athletes

What to expect

  1. Week 1

    Subtle. Some users notice fatigue lifting first.

  2. Week 4

    Cumulative endurance / recovery improvements for responders.

  3. Week 8

    Plateau. Cycle off.

Looking at SS-31 (Elamipretide / MTP-131)? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for SS-31 (Elamipretide / MTP-131).

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

    A free account saves your stack; membership adds the stack-aware AI Coach.

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How it works (mechanism)

Mitochondria-targeted peptide that concentrates in the inner mitochondrial membrane and binds cardiolipin. Stabilizes the electron transport chain and improves ATP production efficiency under stress.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Generally well tolerated
02Injection-site irritation
03Rare: headache

When NOT to use

  • ⚠Pregnancy / nursing
  • ⚠No data in active malignancy

Common mistakes

  • • Expecting fast effects (it's cumulative)
  • • Running short cycles and quitting before adaptation
  • • Underdosing for therapeutic context
Free, no account needed

New to SS-31 (Elamipretide / MTP-131)? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if SS-31 (Elamipretide / MTP-131) changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about SS-31 (Elamipretide / MTP-131) or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

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Frequently asked

What is SS-31 (Elamipretide / MTP-131)?+
SS-31 (also called Elamipretide or MTP-131) targets your mitochondria, the energy plants inside your cells. It concentrates in the inner mitochondrial membrane and supports ATP production. Used by people with mitochondrial-flavored fatigue and as a longevity adjunct.
Is SS-31 (Elamipretide / MTP-131) FDA approved?+
FDA-approved as FORZINITY (elamipretide) on Sept 19, 2025 under accelerated approval, to improve muscle strength in adult and pediatric Barth syndrome patients weighing >=30 kg. The first FDA-approved mitochondria-targeted drug. Approved only for Barth syndrome, every other use (longevity, general mitochondrial support) is off-label and unapproved.
Is SS-31 (Elamipretide / MTP-131) legal?+
SS-31 (Elamipretide / MTP-131) is FDA-approved and legal to obtain by prescription in the US. Yes for Barth syndrome (FORZINITY, 40 mg sub-q daily), via specialty pharmacy. Not commercially available for off-label longevity use.
Is SS-31 (Elamipretide / MTP-131) banned by WADA?+
SS-31 (Elamipretide / MTP-131) is not currently on the WADA prohibited list.
Are you still natty after taking SS-31 (Elamipretide / MTP-131)?+
No. SS-31 (Elamipretide / MTP-131) is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe SS-31 (Elamipretide / MTP-131)?+
Yes for Barth syndrome (FORZINITY, 40 mg sub-q daily), via specialty pharmacy. Not commercially available for off-label longevity use.
What's the typical dose of SS-31 (Elamipretide / MTP-131)?+
5-40 mg sub-q daily, depending on indication. Most casual users run 5-10 mg.
What are the side effects of SS-31 (Elamipretide / MTP-131)?+
Common side effects include: Generally well tolerated; Injection-site irritation; Rare: headache. Less common effects and full safety details are on the entry page.
How long until SS-31 (Elamipretide / MTP-131) starts working?+
Subtle. Some users notice fatigue lifting first.
What can you stack with SS-31 (Elamipretide / MTP-131)?+
Common pairings: MOTS-c for combined mitochondrial support; Standalone. Full stacking protocol and timing on the entry page.
Where do people get SS-31 (Elamipretide / MTP-131)?+
SS-31 (Elamipretide / MTP-131) is dispensed through licensed pharmacies with a prescription. Some compounding pharmacies and telehealth services prescribe it. Pepdex is not a vendor or pharmacy. See /coa for how to verify Certificate of Analysis on any supplier.

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