LL-37
Cathelicidin-derived antimicrobial peptide your innate immune system already makes. Used for chronic infections and biofilm-associated issues.
LL-37 is an antimicrobial peptide your innate immune system already makes. People use it for chronic infections, biofilms (bacterial slime that resists antibiotics), and immune support. Strong effect in lab data, less data in humans.
Naturally occurring antimicrobial peptide. Federations don't generally cover it.
Not FDA approved.
Not formally categorized in the FDA bulks lists.
Not prescribed in conventional medicine.
Who it's for
- →Users with chronic biofilm-associated infections
- →Wound-healing contexts
- →Stack add-on for aggressive immune protocols
What to expect
- Week 1
Subtle. Mild flu-like symptoms in first few doses for some users.
- Week 4
Full cycle. Reassess infection markers.
- Week 8
Off-cycle.
How it works (mechanism)
Cathelicidin-derived antimicrobial peptide (the human cathelicidin family's only member). Disrupts bacterial membranes through pore formation and modulates innate immune signaling.
Dosing protocol
100-500 mcg sub-q daily for 4 weeks.
Stacks well with
Side effects
When NOT to use
- ⚠Mast cell activation syndrome (MCAS)
- ⚠Pregnancy / nursing
Bloodwork to monitor
- • CBC if running long courses
Common mistakes
- • Treating it as a substitute for antibiotics (it's adjunct, not replacement)
- • Pushing dose in MCAS-prone users
- • Skipping the cycle break
Drug & supplement interactions
- ⚠Mast cell activation syndrome (MCAS): may worsen — avoid
- ⚠Limited documented interactions
Educational only. User-specific dosing is between you and a qualified provider.
Frequently asked
What is LL-37?+
Is LL-37 FDA approved?+
Is LL-37 banned by WADA?+
Are you still natty after taking LL-37?+
Do doctors prescribe LL-37?+
What's the typical dose of LL-37?+
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