Pepdexpepdex
My Stack
№ 055

PNC-27

Membranolytic peptide that selectively kills cancer cells expressing HDM-2 (oncoprotein) on the membrane surface. Pre-clinical anti-cancer research compound.

Immune
Evidence: Anecdotal

PNC-27: Membranolytic peptide that selectively kills cancer cells expressing HDM-2 (oncoprotein) on the membrane surface. Pre-clinical anti-cancer research compound. PNC-27 is a peptide that punches holes in cancer-cell membranes by binding HDM-2, an oncoprotein found on tumor cell surfaces.

FDA ⓘ
Not approved
WADA
Not banned
Typical dose
No standardized human dose
Half-life ⓘ
~hours
Route ⓘ
Subcutaneous or IV (research)
Schedule
Daily in research protocols
In plain English

PNC-27 is a peptide that punches holes in cancer-cell membranes by binding HDM-2, an oncoprotein found on tumor cell surfaces. Healthy cells don't express HDM-2 on the surface, so it's selective in theory. Pre-clinical research compound, not approved for treatment.

Status & legalityWhat do these mean? →
Natty? ⓘ
Grey area

Anti-cancer peptide. Federations don't typically address research compounds.

FDA ⓘ
Not approved

Not FDA approved. Pre-clinical research compound.

Compounding ⓘ
Not classified

Not formally categorized in the FDA bulks lists.

WADA ⓘ
Not listed
Prescribed ⓘ

Not prescribed in conventional medicine outside research contexts.

Who it's for

  • →Cancer-research contexts under medical oversight
  • →Educational reference, pre-clinical only
  • →Compassionate-use research scenarios

What to expect

  1. Week 1

    Acute responses in animal/cell models.

  2. Week 4

    Pre-clinical endpoint.

  3. Week 8

    No human long term safety data.

Looking at PNC-27? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for PNC-27.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

    A free account saves your stack; membership adds the stack-aware AI Coach.

    Create free account →

How it works (mechanism)

Membranolytic peptide. Selectively binds HDM-2 (an oncoprotein) found on the membrane surface of cancer cells (rarely on healthy cells), then lyses the cell membrane. Pre-clinical anti-cancer mechanism.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Limited human safety data
02Theoretical off-target membrane effects
03Injection-site reaction

When NOT to use

  • ⚠Anyone without medical oversight
  • ⚠Pregnancy / nursing
  • ⚠Active autoimmune conditions

Bloodwork to monitor

  • • CBC, CMP, LFTs at minimum if researching

Common mistakes

  • • Self-administering for cancer treatment (this is pre-clinical, not approved)
  • • Skipping medical oversight
  • • Long cycles without safety monitoring
Free, no account needed

New to PNC-27? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if PNC-27 changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about PNC-27 or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

Get the Coach, $7.99/mo →

Frequently asked

What is PNC-27?+
PNC-27 is a peptide that punches holes in cancer-cell membranes by binding HDM-2, an oncoprotein found on tumor cell surfaces. Healthy cells don't express HDM-2 on the surface, so it's selective in theory. Pre-clinical research compound, not approved for treatment.
Is PNC-27 FDA approved?+
Not FDA approved. Pre-clinical research compound.
Is PNC-27 legal?+
PNC-27 is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is PNC-27 banned by WADA?+
PNC-27 is not currently on the WADA prohibited list.
Are you still natty after taking PNC-27?+
Grey area. Anti-cancer peptide. Federations don't typically address research compounds.
Do doctors prescribe PNC-27?+
Not prescribed in conventional medicine outside research contexts.
What's the typical dose of PNC-27?+
No standardized human dose. Pre-clinical models use per-kg dosing.
What are the side effects of PNC-27?+
Common side effects include: Limited human safety data; Theoretical off-target membrane effects; Injection-site reaction. Less common effects and full safety details are on the entry page.
How long until PNC-27 starts working?+
Acute responses in animal/cell models.
What can you stack with PNC-27?+
Common pairings: Standalone in research contexts. Full stacking protocol and timing on the entry page.
Where do people get PNC-27?+
PNC-27 is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.

More in Immune

№ 029
Thymosin Alpha-1 (Tα1)

Immune-system peptide. Approved in many countries for hepatitis B/C and as adjunct to chemotherapy. Used here for chronic immune issues and post-illness recovery.

№ 036
LL-37

A germ-fighter your immune system already makes on its own. It's a cathelicidin-derived antimicrobial peptide used for chronic infections and biofilm-associated issues.

№ 057
VIP (Vasoactive Intestinal Peptide)

Endogenous 28-amino-acid neuropeptide. Modulates immune function and inflammation. Used in CIRS (chronic inflammatory response syndrome) protocols and biotoxin exposure recovery, popularized by Dr. Ritchie Shoemaker.

№ 018
KPV

Calms inflammation in the gut and skin. A tripeptide fragment of alpha-MSH used for gut conditions and skin inflammation.