What is the half-life of PNC-27?
PNC-27 has a reported half life of ~hours, given subcutaneous or IV (research). That is why it is typically dosed daily in research protocols. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~hours
- Route: Subcutaneous or IV (research)
- Typical schedule: Daily in research protocols
- Cycle length: Highly variable per protocol
References
- PNC-27, anticancer peptide that selectively kills HDM-2-expressing cancer cells — Michl J et al., Anticancer Res, 2006
- Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing Mitochondrial Disruption — Krzesaj P et al., Annals of Clinical and Laboratory Science, 2024
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.