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№ 051

MGF (Mechano Growth Factor)

Splice variant of IGF-1 produced by muscle in response to mechanical loading and damage. Triggers satellite cell activation. Short half-life, superseded for most use cases by PEG-MGF.

GH-axis
Evidence: Limited

MGF (Mechano Growth Factor): Splice variant of IGF-1 produced by muscle in response to mechanical loading and damage. Triggers satellite cell activation. Short half-life, superseded for most use cases by PEG-MGF. MGF is a splice variant of IGF-1 your muscle makes after damage.

FDA ⓘ
Not approved
WADA
Banned
Typical dose
100-200 mcg sub-q post-workout
Half-life ⓘ
~5-7 minutes
Route ⓘ
Subcutaneous, often near worked muscle
Schedule
Post-workout, 1x daily
In plain English

MGF is a splice variant of IGF-1 your muscle makes after damage. Tells satellite cells to wake up and rebuild. The unmodified version clears in minutes, so it only works locally, most users prefer PEG-MGF for systemic effect.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty

IGF-1 derivative. Universally banned in tested sport.

FDA ⓘ
Not approved

Not FDA approved as a drug.

Compounding ⓘ
Category 2

FDA flagged as significant safety risk; restricted from compounding pharmacies.

WADA ⓘ
Banned (S2)

Falls under the S2 IGF / growth factor category.

Prescribed ⓘ

Not prescribed in conventional medicine.

Who it's for

  • →Lifters experimenting with site-specific muscle anabolism
  • →Post-injury muscle recovery contexts
  • →Researchers preferring short-acting MGF over PEGylated version

What to expect

  1. Week 1

    Acute pumps and fullness in worked muscle.

  2. Week 4

    Subjective recovery improvements. Site-specific tissue responses.

  3. Week 8

    Cycle endpoint reached. Receptor desensitization ramping.

Looking at MGF (Mechano Growth Factor)? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for MGF (Mechano Growth Factor).

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  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

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How it works (mechanism)

Splice variant of IGF-1 produced locally by muscle in response to mechanical loading. Activates satellite cells (muscle stem cells) to proliferate and fuse, the basis of damage-driven hypertrophy. Native form is metabolized in minutes.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Hypoglycemia at higher doses
02Localized tissue growth at injection site
03Headache
04Skin sensitivity at site

When NOT to use

  • ⚠Active malignancy
  • ⚠Diabetic retinopathy
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • IGF-1 baseline + at week 4
  • • Fasting glucose every 2 weeks

Common mistakes

  • • Treating it as long-acting (it isn't, it's metabolized in minutes)
  • • Confusing it with PEG-MGF (different kinetics)
  • • Long cycles without breaks

Drug & supplement interactions

  • ⚠Insulin: hypoglycemia risk
  • ⚠Short half-life means fewer chronic interaction concerns
Free, no account needed

New to MGF (Mechano Growth Factor)? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if MGF (Mechano Growth Factor) changes legal status. No account needed.

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AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about MGF (Mechano Growth Factor) or your own stack. This is it working.

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Frequently asked

What is MGF (Mechano Growth Factor)?+
MGF is a splice variant of IGF-1 your muscle makes after damage. Tells satellite cells to wake up and rebuild. The unmodified version clears in minutes, so it only works locally, most users prefer PEG-MGF for systemic effect.
Is MGF (Mechano Growth Factor) FDA approved?+
Not FDA approved as a drug.
Is MGF (Mechano Growth Factor) legal?+
MGF (Mechano Growth Factor) is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is MGF (Mechano Growth Factor) banned by WADA?+
MGF (Mechano Growth Factor) is on the WADA prohibited list under Banned (S2). Falls under the S2 IGF / growth factor category.
Are you still natty after taking MGF (Mechano Growth Factor)?+
No. IGF-1 derivative. Universally banned in tested sport.
Do doctors prescribe MGF (Mechano Growth Factor)?+
Not prescribed in conventional medicine.
What's the typical dose of MGF (Mechano Growth Factor)?+
100-200 mcg sub-q post-workout, near the trained muscle.
What are the side effects of MGF (Mechano Growth Factor)?+
Common side effects include: Hypoglycemia at higher doses; Localized tissue growth at injection site; Headache; Skin sensitivity at site. Less common effects and full safety details are on the entry page.
How long until MGF (Mechano Growth Factor) starts working?+
Acute pumps and fullness in worked muscle.
What can you stack with MGF (Mechano Growth Factor)?+
Common pairings: IGF-1 LR3 (cautiously, both anabolic), generally not recommended together; Standalone is preferred. Full stacking protocol and timing on the entry page.
Where do people get MGF (Mechano Growth Factor)?+
MGF (Mechano Growth Factor) is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.

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