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№ 050

FOXO4-DRI

FOXO4 dominant-negative interfering peptide. Selectively triggers apoptosis in senescent cells by disrupting FOXO4-p53 interaction. Animal-model senolytic with strong age-reversal data in mice.

Longevity
Evidence: Limited

FOXO4-DRI: FOXO4 dominant-negative interfering peptide. Selectively triggers apoptosis in senescent cells by disrupting FOXO4-p53 interaction. Animal-model senolytic with strong age-reversal data in mice. FOXO4-DRI is a senolytic peptide, it selectively kills senescent ('zombie') cells that accumulate with age and drive inflammation.

FDA ⓘ
Not approved
WADA
Not banned
Typical dose
No standardized human dose
Half-life ⓘ
~hours
Route ⓘ
Subcutaneous
Schedule
Pulsed dosing, not continuous
In plain English

FOXO4-DRI is a senolytic peptide, it selectively kills senescent ('zombie') cells that accumulate with age and drive inflammation. The mouse data is dramatic: improved fur, kidney function, fitness in old mice. Human data is essentially nonexistent.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Not FDA approved. Pre-clinical research compound (animal-model senolytic data).

Compounding ⓘ
Not classified

Not formally categorized in the FDA bulks lists.

WADA ⓘ
Not listed
Prescribed ⓘ

Not prescribed in conventional medicine.

Who it's for

  • →Researchers studying senolytics
  • →Longevity-research contexts under medical guidance
  • →Educational reference, limited human safety data

What to expect

  1. Week 1

    Mouse-model markers (improved fur density, kidney function, fitness) emerged within 10 days.

  2. Week 4

    Off-pulse. Effects in mice persisted for weeks.

  3. Week 8

    No human long term data exists.

Looking at FOXO4-DRI? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for FOXO4-DRI.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

Dominant-negative interfering peptide that disrupts the FOXO4-p53 interaction. In senescent cells, FOXO4 normally protects against p53-driven apoptosis; blocking the interaction selectively triggers death of senescent ('zombie') cells.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Limited human safety data
02Theoretical: off-target apoptosis in healthy tissue
03Injection-site reaction

When NOT to use

  • ⚠Active malignancy (apoptotic effects on cells in unstable states)
  • ⚠Pregnancy / nursing
  • ⚠Anyone risk-averse to pre-clinical-only data

Bloodwork to monitor

  • • CBC and basic metabolic panel if researching

Common mistakes

  • • Treating it as a longevity 'drug' (it's pre-clinical)
  • • Running long cycles instead of short pulses
  • • Stacking with other experimental compounds
Free, no account needed

New to FOXO4-DRI? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if FOXO4-DRI changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about FOXO4-DRI or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

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Frequently asked

What is FOXO4-DRI?+
FOXO4-DRI is a senolytic peptide, it selectively kills senescent ('zombie') cells that accumulate with age and drive inflammation. The mouse data is dramatic: improved fur, kidney function, fitness in old mice. Human data is essentially nonexistent.
Is FOXO4-DRI FDA approved?+
Not FDA approved. Pre-clinical research compound (animal-model senolytic data).
Is FOXO4-DRI legal?+
FOXO4-DRI is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is FOXO4-DRI banned by WADA?+
FOXO4-DRI is not currently on the WADA prohibited list.
Are you still natty after taking FOXO4-DRI?+
No. FOXO4-DRI is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe FOXO4-DRI?+
Not prescribed in conventional medicine.
What's the typical dose of FOXO4-DRI?+
No standardized human dose. Mouse-model dosing pulsed at 5 mg/kg every other day for 3 doses.
What are the side effects of FOXO4-DRI?+
Common side effects include: Limited human safety data; Theoretical: off-target apoptosis in healthy tissue; Injection-site reaction. Less common effects and full safety details are on the entry page.
How long until FOXO4-DRI starts working?+
Mouse-model markers (improved fur density, kidney function, fitness) emerged within 10 days.
What can you stack with FOXO4-DRI?+
Common pairings: Standalone, senolytic effect is the whole point. Full stacking protocol and timing on the entry page.
Where do people get FOXO4-DRI?+
FOXO4-DRI is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.

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