What is the half-life of FOXO4-DRI?
FOXO4-DRI has a reported half life of ~hours, given subcutaneous. That is why it is typically dosed pulsed dosing, not continuous. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~hours
- Route: Subcutaneous
- Typical schedule: Pulsed dosing, not continuous
- Cycle length: Short pulses (3-5 days)
References
- Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging — Baar MP et al., Cell, 2017
- Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline — Alameen AAM et al., Naunyn-Schmiedeberg's Arch Pharmacol, 2026
- FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation — Kong YX et al., Communications Biology, 2025
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.