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№ 038

Humanin

Mitochondrial-derived peptide encoded inside mitochondrial DNA. Studied for neuroprotection, insulin sensitivity, cellular survival.

Longevity
Evidence: Limited
Half-life
~minutes (rapid clearance)
Route
Subcutaneous
Cycle
4-8 weeks
Schedule
Daily
In plain English

Humanin is a peptide your mitochondria make and secrete. It's tied to neuroprotection, insulin sensitivity, and cellular survival. Slow, subtle effects — mostly used as a longevity-stack add-on.

Status & legality
Natty?
Grey area

Mitochondrial-derived peptide. Naturally produced; exogenous use is a different question.

FDA
Not approved

Not FDA approved.

Compounding
Not classified

Not formally categorized in the FDA bulks lists.

WADA
Not listed
Prescribed

Not prescribed in conventional medicine.

Who it's for

  • →Users running longevity-focused stacks
  • →Older adults targeting metabolic and neuroprotective markers
  • →Cellular bioenergetics enthusiasts

What to expect

  1. Week 1

    Subtle. Energy and mood lift first for responders.

  2. Week 4

    Cumulative metabolic / cognitive support.

  3. Week 8

    Plateau. Cycle off.

How it works (mechanism)

Mitochondrial-derived peptide encoded inside mitochondrial DNA. Binds receptors that activate STAT3 and reduce apoptosis, particularly in neurons and pancreatic beta cells.

Dosing protocol

1-10 mg sub-q daily. Casual users start at 1-3 mg.

Stacks well with

MOTS-c or SS-31 for compounded mitochondrial protocols
Standalone for longevity

Side effects

01Generally well tolerated
02Limited safety data — short cycles preferred

When NOT to use

  • ⚠Pregnancy / nursing
  • ⚠No data in active malignancy

Bloodwork to monitor

  • • Fasting glucose / insulin if running longer

Common mistakes

  • • Expecting fast or visible effects (it's slow and subtle)
  • • Stacking with too many longevity peptides simultaneously
  • • Running indefinitely — limited human safety data

Educational only. User-specific dosing is between you and a qualified provider.

Frequently asked

What is Humanin?+
Humanin is a peptide your mitochondria make and secrete. It's tied to neuroprotection, insulin sensitivity, and cellular survival. Slow, subtle effects — mostly used as a longevity-stack add-on.
Is Humanin FDA approved?+
Not FDA approved.
Is Humanin banned by WADA?+
Humanin is not currently on the WADA prohibited list.
Are you still natty after taking Humanin?+
Grey area. Mitochondrial-derived peptide. Naturally produced; exogenous use is a different question.
Do doctors prescribe Humanin?+
Not prescribed in conventional medicine.
What's the typical dose of Humanin?+
1-10 mg sub-q daily. Casual users start at 1-3 mg.
What are the side effects of Humanin?+
Common side effects include: Generally well tolerated; Limited safety data — short cycles preferred. Less common effects and full safety details are on the entry page.
How long until Humanin starts working?+
Subtle. Energy and mood lift first for responders.

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