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Adderall

Mixed amphetamine salts · Stimulant (amphetamine)

Research reference only. Pepdex does not sell, supply or track this compound, and nothing here is guidance to use it — this page exists so the evidence and the risks are visible.

What it is

Prescription mixed amphetamine salts for ADHD and narcolepsy, and the most widely diverted "study drug" in the US. It reliably increases wakefulness, motivation and confidence in a session of work — which is exactly why its cognitive benefit is overestimated by the people using it.

What human evidence shows

For diagnosed ADHD, effect sizes are large and the evidence is excellent. For neurotypical enhancement the literature is sobering: objective gains on complex cognition are small to absent, while users consistently RATE their own performance as improved — a documented perception gap. It improves task engagement more than task ability.

Risks

Real dependence potential — this is a Schedule II amphetamine, and tolerance-driven dose escalation is the standard failure mode. Cardiovascular load (heart rate, blood pressure), appetite and sleep destruction, anxiety, and in vulnerable people psychosis at high exposure. Withdrawal is a genuine crash. Combining with other stimulants or MAOIs is dangerous. Counterfeit pills pressed with fentanyl are a documented, recurring cause of death in people who thought they were buying Adderall.

Stacking interactions

Documented interactions with other things people research. A compound not listed here does not mean the combination is safe — only that no specific interaction is on file.

CautionClenbuterol

Concurrent exposure to agents with sympathomimetic cardiovascular effects may further increase heart rate, blood pressure, or arrhythmia risk; pair-specific evidence varies.

CautionDMAA

Concurrent exposure to agents with sympathomimetic cardiovascular effects may further increase heart rate, blood pressure, or arrhythmia risk; pair-specific evidence varies.

CautionThyroid hormones (T3 / T4)

Concurrent exposure to agents with sympathomimetic cardiovascular effects may further increase heart rate, blood pressure, or arrhythmia risk; pair-specific evidence varies.

CautionTesofensine

Concurrent exposure to agents with sympathomimetic cardiovascular effects may further increase heart rate, blood pressure, or arrhythmia risk; pair-specific evidence varies.

CautionCaffeine

Concurrent exposure to agents with sympathomimetic cardiovascular effects may further increase heart rate, blood pressure, or arrhythmia risk; pair-specific evidence varies.

Legal status

US: Schedule II — possession without a prescription is a felony in most states. There is no legal grey-market version; anything bought outside a pharmacy is either diverted or counterfeit.

Evidence base

A301 research papers
substantial literature

Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.

phase 3/4
0
randomised
37
reviews
6
human trials
46

Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.

Research (12)

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Where next

Every compound in the catalogThe full non-peptide index, with evidence grades.→The peptide indexInjectable peptides, half-lives and what trials used.→Spotting a scam vendorRed flags, COA checks and what traceability looks like.→