Adipotide
FTPP / Prohibitin-TP01 · Peptidomimetic (experimental fat-tissue ablation)
What it is
An experimental compound designed to kill the blood vessels feeding white fat tissue — targeted vascular destruction as a weight-loss strategy. The monkey studies that made it famous also documented kidney injury.
What human evidence shows
Rhesus monkey studies showed real fat loss. The identical papers document renal tubular damage — dose-dependent kidney injury was IN the headline research, not a later discovery. A small human oncology trial was registered years ago; no results have translated into any approval path.
Risks
Kidney toxicity is the documented, primary-source risk, and vascular ablation is not a reversible lever like appetite. The compound's own supporting literature carries its organ-damage signal.
Legal status
US: unapproved investigational compound.
Evidence base
very early literature
Almost no published research of any kind.
- phase 3/4
- 0
- randomised
- 0
- reviews
- 0
- human trials
- 0
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (4)
- A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeysSci Transl Med · 2011
- A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medicationJ Control Release · 2013
- Comment on "a peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys"Sci Transl Med · 2012
- Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetesSci Transl Med · 2020
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