Arimistane
Androsta-3,5-diene-7,17-dione / androstenedione derivative · Aromatase inhibitor (OTC-marketed)
What it is
A steroidal aromatase inhibitor that sold for years as a legal "PCT supplement" — the over-the-counter cousin of exemestane, common in post-SARM stacks and hormone products aimed at gym-store shelves.
What human evidence shows
Human efficacy and safety data are inadequate — its estrogen-lowering activity is inferred from structural chemistry and community bloodwork, not trials. It is prohibited in sport.
Risks
The adverse effects of excessive estrogen suppression documented for prescription aromatase inhibitors (joints, libido, mood, lipids, bone) are plausible risks here too, not documented outcomes — with the added problem that actual content of supplement-era products was famously variable. The FDA has moved against it as an unapproved new drug.
Legal status
US: FDA-warned unapproved ingredient — not legally a dietary supplement; WADA-banned.
Evidence base
early literature
Almost no published research of any kind.
- phase 3/4
- 0
- randomised
- 0
- reviews
- 0
- human trials
- 0
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (6)
- Arimistane: Degradation product or metabolite of 7-oxo-DHEA?Drug Test Anal · 2021
- Detection of urinary arimistane metabolites in humans using liquid chromatography-mass spectrometry: Complementary results to gas chromatography mass spectrometric data and its application to antidoping analysesRapid Commun Mass Spectrom · 2021
- Detection of urinary metabolites of arimistane in humans by gas chromatography coupled to high-accuracy mass spectrometry for antidoping analysesRapid Commun Mass Spectrom · 2019
- 7-keto-DHEAmetabolism in humans. Pitfalls in interpreting the analytical results in the antidoping fieldDrug Test Anal · 2019
- Mass spectrometric analysis of 7-oxygenated androst-5-ene structures. Influence in trimethylsilyl derivative formationRapid Commun Mass Spectrom · 2020
- The power of hyphenated chromatography-Time of flight mass spectrometry for unequivocal identification of spirostanes in bodybuilding dietary supplementsJ Pharm Biomed Anal · 2019
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