BAM15
Mitochondrial uncoupler · Mitochondrial uncoupler (unapproved)
What it is
A research uncoupler — same mechanism family as DNP (making mitochondria waste calories as heat) — promoted on mouse studies showing fat loss without DNP's hyperthermia signature.
What human evidence shows
Mouse and cell data only. "Safer than DNP in mice" is the entire safety claim, and DNP set the bar at "kills people," so clearing it means little. No human has been studied.
Risks
Uncoupling is the highest-stakes mechanism in metabolism — DNP's fatality record (see that entry) is mechanism-driven, and BAM15 shares the mechanism with a dose-response curve mapped only in rodents. Human margin of safety: unknown. This entry exists because the name circulates, not because the mouse data transfers.
Legal status
US: not FDA-approved for human use; unscheduled.
Evidence base
emerging literature
Studied, but no human trial report found. A real literature that is preclinical as far as these counts can see.
- phase 3/4
- 0
- randomised
- 0
- reviews
- 0
- human trials
- 0
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophilsJ Clin Invest · 2023
- BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseasesFront Endocrinol (Lausanne) · 2023
- BAM15 inhibits endothelial pyroptosis via the NLRP3/ASC/caspase-1 pathway to alleviate atherosclerosisAtherosclerosis · 2025
- Beneficial effects of MGL-3196 and BAM15 combination in a mouse model of fatty liver diseaseActa Physiol (Oxf) · 2024
- BAM15 Relieves Neurodegeneration in Aged Caenorhabditis elegans and Extends LifespanMetabolites · 2022
- BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissueStem Cell Res Ther · 2019
- BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic controlEMBO Mol Med · 2020
- The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemiaBiochem Pharmacol · 2022
- BAM15 improves oocyte quality against obesity via PPARγ-dependent mitochondrial functionProtein Cell · 2026
- Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality controlJ Cachexia Sarcopenia Muscle · 2022
- Targeting Mitochondrial Dysfunction to Prevent Endothelial Dysfunction and Atherosclerosis in Diabetes: Focus on the Novel Uncoupler BAM15Int J Mol Sci · 2025
- BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and HepatocytesJ Innate Immun · 2021
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