Bromantane
Ladasten · Atypical psychostimulant / actoprotector
What it is
A Russian-developed "actoprotector" — a compound claimed to enhance physical and mental resilience without classical stimulant effects. Acts partly by upregulating dopamine synthesis enzymes rather than blocking reuptake.
What human evidence shows
Nearly all published research is Russian, much of it from the Soviet/post-Soviet sports-science program, with small samples and limited methodology visible in English-language literature. A Russian clinical trial reported benefit in asthenia (fatigue syndromes). Western replication is essentially absent — by the evidence standards this app applies to peptides, bromantane grades as Anecdotal-to-Limited.
Risks
The honest risk statement is that the safety profile is poorly characterized in Western literature — an absence of documented harms in small foreign trials is not evidence of safety. Banned by WADA as a stimulant and masking agent since 1997, which reflects both its use history and detectability concerns.
Legal status
US: not approved, not scheduled — sold as a "research chemical" with no quality oversight. WADA-banned in sport. Prescription drug in Russia.
Evidence base
emerging literature
Studied, but no human trial report found. A real literature that is preclinical as far as these counts can see.
- phase 3/4
- 0
- randomised
- 0
- reviews
- 1
- human trials
- 0
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- Plant Adaptogens-History and Future PerspectivesNutrients · 2021
- Toxic effect of single treatment with bromantane on neurological status of experimental animalsBull Exp Biol Med · 2002
- [Study of heat-protective effects of bromantane at various levels of overheating]Vopr Med Khim · 1995
- [An acute toxicity study of bromantane]Eksp Klin Farmakol · 2000
- [The effect of bromantane on the physical work capacity of laboratory animals]Eksp Klin Farmakol · 1998
- [Analysis of pharmacological properties of bromantane]Biull Eksp Biol Med · 1999
- [A quantitative pharmaco-electroencephalographic analysis of the action of bromantane]Biull Eksp Biol Med · 1993
- [Effect of bromantane on the rat neurologic status in two month course]Eksp Klin Farmakol · 2000
- [The effect of bromantane on the cardiovascular and sympathetic-adrenal systems in animals]Eksp Klin Farmakol · 2000
- [Effects of bromantane and sidnocarb on long-term operant conditioning and its vegetative correlates in rats]Eksp Klin Farmakol · 2000
- [The neuro- and psychophysiological effects of bromantane]Voen Med Zh · 2000
- [The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain]Eksp Klin Farmakol · 1995
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