Cabergoline
Dostinex / caber · Dopamine agonist (prolactin control)
What it is
A prescription dopamine agonist for prolactinomas, which also circulates in AAS contexts on the theory of managing prolactin-pattern side effects (and for libido folklore).
What human evidence shows
Excellent evidence for its actual indication — it is the standard prolactinoma drug. Evidence for steroid-cycle prolactin management: extrapolated, plausible, never trialed. The libido folklore traces to small studies in medical contexts, inflated in the retelling.
Risks
Fibrotic heart-valve disease is established at the high cumulative exposures used in Parkinson's disease; risk at lower exposures appears smaller but remains actively monitored in medicine — and unmonitored entirely outside it. Impulse-control disorders are a documented dopamine-agonist class effect: gambling, compulsive behavior — real published case reports, exactly the failure mode a user won't self-detect. Nausea and orthostatic drops round it out.
Legal status
US: prescription-only. Products outside licensed dispensing are unapproved and of unverifiable authenticity.
Evidence base
established literature
Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.
- phase 3/4
- 2
- randomised
- 107
- reviews
- 80
- human trials
- 214
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- Cabergoline2006
- Cabergoline in acromegalyPituitary · 2017
- Cabergoline: a review of its use in the inhibition of lactation for women living with HIVJ Int AIDS Soc · 2019
- Pituitary acting drugs: cabergoline and pasireotidePituitary · 2022
- Approach to the Patient With ProlactinomaJ Clin Endocrinol Metab · 2023
- Cabergoline-induced manic episode: case reportTher Adv Psychopharmacol · 2016
- Cabergoline Use and Pregnancy Outcomes: A Systematic ReviewBirth Defects Res · 2025
- Real-world value of cabergoline in the treatment of acromegalyBest Pract Res Clin Endocrinol Metab · 2024
- Is Cabergoline Safe and Effective for Postpartum Lactation Inhibition? A Systematic ReviewInt J Womens Health · 2020
- Safety of Cabergoline for Prolactinoma in Pregnancy: A Systematic Review and Meta-AnalysisClin Endocrinol (Oxf) · 2025
- Safety of Cabergoline for Postpartum Lactation Inhibition or Suppression: A Systematic ReviewJ Obstet Gynaecol Can · 2020
- Cabergoline for preventing ovarian hyperstimulation syndromeCochrane Database Syst Rev · 2012
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