DHB (Dihydroboldenone)
1-testosterone / 1-test cyp · Anabolic steroid (injectable)
What it is
A boldenone relative with no human clinical development — it briefly circulated as a "prohormone" in the 2000s and now exists only as an unapproved product.
What human evidence shows
No human clinical program, period. Animal assay data from mid-century pharmacology plus modern community anecdote is the entire record — every claim about its profile is extrapolation.
Risks
Injection-site reactions are widely reported, with incidence unknown. Long-term profile is entirely uncharacterized, plus the assumed full AAS package: HPG-axis suppression, lipid and cardiovascular strain. An unstudied steroid with no approved manufacturer is two layers of unknown, and both are load-bearing.
Legal status
US: 1-testosterone is explicitly listed as a Schedule III anabolic steroid under the CSA.
Evidence base
substantial literature
Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.
- phase 3/4
- 1
- randomised
- 35
- reviews
- 3
- human trials
- 43
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- Supplementing With Which Form of Creatine (Hydrochloride or Monohydrate) Alongside Resistance Training Can Have More Impacts on Anabolic/Catabolic Hormones, Strength and Body Composition?Physiol Res · 2024
- Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With ExerciseFront Endocrinol (Lausanne) · 2020
- ErratumNeuroendocrinology · 2026
- Testosterone concentrations and prescription patterns of 1% testosterone gel in transgender and gender diverse individualsTher Adv Endocrinol Metab · 2022
- Testim 1% testosterone gel for the treatment of male hypogonadismClin Ther · 2005
- Metabolic studies of 1-testosterone in horsesDrug Test Anal · 2013
- Testosterone therapy--what, when and to whom?Aging Male · 2004
- No effect of testosterone or sexual ornamentation on telomere dynamics: A case study and meta-analysesEcol Evol · 2024
- Testosterone replacement with 1% testosterone gel and priapism: no definite risk relationshipJ Sex Med · 2013
- Effect of acute exercise on the dynamics of testosterone levels: a systematic review of randomized controlled trialsPeerJ · 2026
- The relationship between circulating testosterone and inflammatory cytokines in menAging Male · 2019
- Review of Testim gelExpert Opin Pharmacother · 2006
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