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DNP

2,4-Dinitrophenol · Mitochondrial uncoupler — DO NOT USE

Research reference only. Pepdex does not sell, supply or track this compound, and nothing here is guidance to use it — this page exists so the evidence and the risks are visible.

What it is

An industrial chemical that uncouples mitochondrial respiration, forcing calories out as heat. It produces the fastest fat loss of any known compound, which is why it never fully dies — and it is in this catalog for one reason: so the honest entry outranks the forum one.

What human evidence shows

It works. That was established in the 1930s, when it was sold as a diet drug and then banned after users died and others were blinded by cataracts. The mechanism has no ceiling: the margin between an "effective" exposure and a fatal one is narrow, varies by person, and moves with heat and activity.

Risks

Death by uncontrollable hyperthermia — you overheat from the inside and there is no antidote, no off-switch, and supportive care often fails. Deaths are documented every year, typically young men who "did the research". Cataracts, peripheral neuropathy, skin reactions. Grey-market capsules have wildly variable actual content, which turns even a "conservative" plan into roulette. There is no monitored, safe way to use DNP. None.

Legal status

US: banned for human consumption; sellers have been prosecuted for manslaughter. Sold as a "fertilizer/pesticide" wink online.

Evidence base

A12,294 research papers
established literature

Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.

phase 3/4
1
randomised
49
reviews
53
human trials
69

Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.

Research (12)

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Where next

Every compound in the catalogThe full non-peptide index, with evidence grades.→The peptide indexInjectable peptides, half-lives and what trials used.→Spotting a scam vendorRed flags, COA checks and what traceability looks like.→