Emoxypine
Mexidol / emoxypine succinate · Antioxidant / anxiolytic (Russian pharmaceutical)
What it is
A Russian prescription drug (Mexidol) used there for anxiety, stroke recovery, and "neuroprotection" — structurally related to vitamin B6, pitched in Western nootropic markets as a gentle anxiolytic without sedation.
What human evidence shows
A substantial Russian clinical literature that Western review standards struggle with: many trials, mostly small, mostly unblinded, essentially none replicated outside the country — the same evidentiary shape as bromantane (see that entry). By this app's tiering it grades Limited: real drug, real usage history, unverifiable claims.
Risks
Russian prescribing lists mild effects (nausea, drowsiness at higher exposures), and its decades of clinical use there are weak-but-real safety evidence. The practical risks are product quality outside its home market and the general problem of self-treating anxiety on evidence with limited independent replication and uncertain applicability under modern trial standards.
Legal status
US: unapproved, unscheduled; prescription pharmaceutical in Russia/CIS.
Evidence base
substantial literature
Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.
- phase 3/4
- 0
- randomised
- 40
- reviews
- 2
- human trials
- 70
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- Promising effects of emoxypine and its succinate derivative in the management of various diseases-with insights on recent patent applicationsCurr Res Pharmacol Drug Discov · 2022
- Emoxypine succinate modulates behavioral and molecular responses in zebrafish model of iron Overload-Induced neuroinflammation via CDK5/GSK3- β and NLRP3 inflammasome pathwayBrain Res · 2025
- Pharmaceutical salts of emoxypine with dicarboxylic acidsActa Crystallogr C Struct Chem · 2018
- Emoxypine as a Potential Marker for Identifying Possible Cases of Unintended Meldonium Doping in SportsDrug Test Anal · 2026
- Mexidol, Cytoflavin, and succinic acid derivatives as antihypoxic, anti-ischemic metabolic modulators, and ergogenic aids in athletes and consideration of their potential as performance enhancing drugsDrug Test Anal · 2024
- [Effect of magnesium, acetylsalicilic acid and emoxypine on aggregation of platelets]Biofizika · 2014
- [The effect of the synthetic antioxidant emoxypine on the tonus of the coronary vessels]Farmakol Toksikol · 1989
- [Efficacy of emoxypine in combined therapy for elderly patients with postinfarct cardiosclerosis and heart failure]Klin Med (Mosk) · 2004
- [Effect of mexidol, emoxypine, and dimephosphon on electrophysiological effects of nibentan]Eksp Klin Farmakol · 2002
- [Effect of emoxypine on myocardial electrical instability and homeostasis parameters in patients with acute disturbance of cerebrovascular circulation]Eksp Klin Farmakol · 2002
- [The effect of rubomycin, mexidol and emoxypine on some metabolic indexes and the proccess of spontaneous metastasis under conditions of experimental neoplasia]Eksp Klin Farmakol · 2007
- [Effect of ascorbic acid and emoxypine on the dynamics of the quantitative roentgenological and clinical semiology parameters during infiltrative tuberculosis of lungs]Eksp Klin Farmakol · 2009
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