Fladrafinil
CRL-40,941 / fluorinated adrafinil · Wakefulness agent (research chemical)
What it is
A fluorinated cousin of adrafinil — the old prodrug that converts to modafinil-family compounds in the liver. Related entries: Modafinil and Armodafinil.
What human evidence shows
A 1970s-80s French patent-era literature and almost nothing modern: no therapeutic efficacy trials exist; limited human metabolism data (a small 2026 volunteer study characterizing conversion) is the extent of the modern record. Everything users expect from it is borrowed from modafinil's dossier.
Risks
Adrafinil-class compounds carry a specific concern the modafinil entry does not: the prodrug conversion step works the liver, and adrafinil's own history includes hepatic-enzyme elevation reports with chronic use — fladrafinil inherits the question without the monitoring. Add unverifiable purity and the usual sleep-architecture costs of any long-half-life wakefulness agent.
Legal status
US: unscheduled and not FDA-approved for human use. (Modafinil itself is Schedule IV.)
Evidence base
very early literature
Almost no published research of any kind.
- phase 3/4
- 0
- randomised
- 0
- reviews
- 0
- human trials
- 0
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (1)
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