Halotestin
Fluoxymesterone / Halo · Anabolic steroid (oral)
What it is
An oral androgen with old prescription history (hypogonadism, breast cancer). Non-medical strength-sport use is reported, but controlled performance evidence is absent.
What human evidence shows
The prescription-era record proves biological activity. The strength-sport reputation rests entirely on athlete anecdote — pharmacologically plausible androgen-CNS effects, never trialed.
Risks
Among the most hepatotoxic orals in the published record, severe lipid disruption over short exposures, blood-pressure elevation, and a reported behavioral signature — irritability and aggression that users describe as the effect and the people around them experience as the problem. HPG-axis suppression is marked.
Stacking interactions
Documented interactions with other things people research. A compound not listed here does not mean the combination is safe — only that no specific interaction is on file.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Legal status
US: Schedule III anabolic steroid under the CSA. Historically FDA-approved; current marketing status should be verified against the Orange Book.
Evidence base
substantial literature
Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.
- phase 3/4
- 3
- randomised
- 39
- reviews
- 1
- human trials
- 65
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- FLUOXYMESTERONEJ Am Med Assoc · 1957
- Fluoxymesterone; a new oral androgenBr Med J · 1959
- Fluoxymesterone-induced gynaecomastia in a patient with childhood aplastic anaemiaBMJ Case Rep · 2015
- Acceleration of delayed growth with fluoxymesteroneActa Paediatr Scand · 1982
- Fluoxymesterone ("halotestin"): a new androgenMed J Aust · 1959
- Fluoxymesterone and the development of sexual behavior in the golden hamsterDev Psychobiol · 1981
- Impact of androgen receptor expression in fluoxymesterone-treated estrogen receptor-positive metastatic breast cancer refractory to contemporary hormonal therapyBreast Cancer Res Treat · 2016
- Fluoxymesterone therapy in advanced breast cancerN Engl J Med · 1958
- The effects of fluoxymesterone administration on testicular functionJ Clin Endocrinol Metab · 1977
- [Anabolic action of fluoxymesterone]Dia Med · 1959
- Evaluation of tamoxifen doses with and without fluoxymesterone in advanced breast cancerAnn Intern Med · 1983
- [Fluoxymesterone in gynecological hormone therapy]Riv Ostet Ginecol Prat · 1959
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