Anadrol
Oxymetholone / Adrol / A50 · Anabolic steroid (oral)
What it is
A potent oral steroid developed for anemia; it has been misused for physique and strength enhancement.
What human evidence shows
Prescription-era trials in anemia document potent erythropoiesis and weight gain. The same record documents side effects arriving as fast as the weight does — and much of the rapid scale weight is water that leaves when the drug does.
Risks
Severe on multiple axes at once: pronounced 17-alpha-alkylated liver strain, heavy water retention and blood-pressure elevation, headaches, appetite suppression at higher exposures, edema and gynecomastia-like effects that can occur despite the drug not aromatizing (mechanism not fully established), lipid damage, and marked HPG-axis suppression.
Stacking interactions
Documented interactions with other things people research. A compound not listed here does not mean the combination is safe — only that no specific interaction is on file.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Each of these oral steroids has independently been associated with liver injury. Pair-specific safety data are lacking, and concurrent exposure may increase hepatic risk.
Legal status
US: Schedule III anabolic steroid under the CSA. Historically FDA-approved (Anadrol-50); current marketing status should be verified against the Orange Book.
Evidence base
established literature
Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.
- phase 3/4
- 1
- randomised
- 13
- reviews
- 1
- human trials
- 31
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- OxymetholoneRep Carcinog · 2004
- OxymetholoneBETA · 1998
- OxymetholoneRep Carcinog · 2011
- OxymetholoneRep Carcinog · 2002
- Review of oxymetholone: a 17alpha-alkylated anabolic-androgenic steroidClin Ther · 2001
- Synthesis of a human long-term oxymetholone metaboliteSteroids · 2019
- Effects of Platelet-Rich Plasma on the Oxymetholone-Induced Testicular ToxicityDiseases · 2023
- Oxymetholone in refractory anaemiaBr J Haematol · 1969
- Oxymetholone hepatotoxicity enhanced by concomitant use of cyclosporin A in a bone marrow transplant patientClin Lab Haematol · 1994
- Good response to oxymetholone in adult aplastic anemiaAnn Hematol · 2025
- Oxymetholone treatment for sickle cell anemiaBlood · 1975
- Hereditary angioedemaInt J Dermatol · 1983
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