Primobolan
Methenolone / Primo · Anabolic-androgenic steroid
What it is
An injectable (enanthate) or oral (acetate) anabolic steroid with a reputation as one of the "mildest" AAS — moderate anabolic effect, low androgenic load, no aromatization to estrogen. That reputation, plus its association with physique sport, keeps it perpetually popular and perpetually faked.
What human evidence shows
Almost no modern clinical literature — it had niche medical uses decades ago (wasting, some anemias) and has largely vanished from medicine. What is known: it builds less mass than testosterone at comparable exposure, does not aromatize, and still suppresses natural testosterone production like every AAS. "Mild" describes side-effect intensity, not safety.
Risks
Full HPTA suppression — natural testosterone shuts down, and recovery after stopping is neither fast nor guaranteed. Lipid damage (HDL crushed), cardiac remodeling risk with extended use, hair loss in the predisposed. Because real methenolone is expensive, it is among the most counterfeited steroids — much of what is sold as "primo" is testosterone or nothing. No aromatization means no estrogen bloat, which quietly tempts people into longer exposure.
Legal status
US: Schedule III controlled substance. Unmanufactured in the US — everything on the grey market is imported or underground.
Evidence base
early literature
Early human evidence: at least one human trial report, and not much beyond it.
- phase 3/4
- 0
- randomised
- 0
- reviews
- 0
- human trials
- 1
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- [CLINICAL USE OF PROTEIN ANABOLIC STEROID "PRIMOBOLAN" FOR UROLOGICAL DISEASES]Hinyokika Kiyo · 1964
- [Methenolone enanthate (primobolan depot) in postoperative therapy]Med Welt · 1962
- Detection and quantitation of 3 alpha-hydroxy-1-methylen-5 alpha-androstan-17-one, the major urinary metabolite of methenolone acetate (Primobolan) by isotope dilution--mass spectrometryJ Steroid Biochem · 1983
- [ON THE MECHANISM OF ACTION OF 1-METHYL-1-ANDROSTEN-17-BETA-OL-3-ONE-17-BETA-ACETATE (PRIMOBOLAN)]Z Gesamte Exp Med · 1963
- [EXPERIMENTAL INVESTIGATION ON THE ANTICATABOLIC ACTION OF 1-METHYL-L-ANDROSTENE-17-BETA-OL-3-ONE (PRIMOBOLAN-SCHERING)]Acta Endocrinol (Copenh) · 1964
- Studies on anabolic steroids--4. Identification of new urinary metabolites of methenolone acetate (Primobolan) in human by gas chromatography/mass spectrometryJ Steroid Biochem Mol Biol · 1990
- [Clinical contribution to the use of Primobolan in hepatopathy]Med Welt · 1963
- [Age-related anabolic effect of primobolan in animal experiments]Monatsschr Kinderheilkd (1902) · 1970
- [Therapeutic application of anabolising drugs in gastroenterology. Apropos of Primobolan-Dépôt]Gaz Med Fr · 1965
- Treatment of disseminated carcinoma of the breast by metenolone enanthateActa Radiol Ther Phys Biol · 1975
- Treatment of refractory anemias with methenoloneActa Med Scand · 1979
- The incidence of anabolic steroid use among competitive bodybuildersJ Drug Educ · 1989
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