Proviron
Mesterolone · Oral androgen (anabolic steroid)
What it is
An oral DHT derivative with weak anabolic activity, historically prescribed in Europe for androgen deficiency and as an infertility adjunct. It also circulates in non-medical AAS contexts.
What human evidence shows
Decades of European prescription use — modest, real androgenic effects, including mood and libido findings in older trials. Nothing about its physique-context reputation has controlled evidence behind it.
Risks
Milder than most entries in this class but not free: hair-loss pressure (it is essentially oral DHT), lipid effects, and HPG-axis suppression that users routinely underestimate because the drug "feels" mild. Counterfeits are common in the products that circulate.
Legal status
US: Schedule III anabolic steroid under the CSA; never FDA-approved. A prescription pharmaceutical in parts of Europe.
Evidence base
substantial literature
Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.
- phase 3/4
- 0
- randomised
- 13
- reviews
- 2
- human trials
- 28
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- Differential response of oxidative and glycolytic skeletal muscle fibers to mesteroloneSci Rep · 2021
- Microbial transformation of mesteroloneChem Biodivers · 2005
- Mesterolone treatment of patients with pathospermiaInt Urol Nephrol · 1978
- Mesterolone and idiopathic male infertility: a double-blind study. World Health Organization Task Force on the Diagnosis and Treatment of InfertilityInt J Androl · 1989
- New potential biomarkers for mesterolone misuse in human urine by liquid chromatography quadrupole time-of-flight mass spectrometryJ Mass Spectrom · 2015
- Influence of mesterolone on satellite cell distribution and fiber morphology within maturing chicken pectoralis muscleAnat Rec (Hoboken) · 2012
- Psychopharmacological profile of mesterolonePol J Pharmacol Pharm · 1981
- Morphological changes in murine skeletal muscle in response to exercise and mesteroloneJ Electron Microsc (Tokyo) · 2010
- Mesterolone: a new androgenDrug Ther Bull · 1972
- A Validated TLC-Densitometric Method for the Determination of Mesterolone in Bulk Material and in TabletsBiomed Res Int · 2015
- Markers of mesterolone abuse in sulfate fraction for doping control in human urineJ Mass Spectrom · 2015
- Drug-induced liver injury due to mesterolone: A case reportGastroenterol Hepatol · 2019
Turn Proviron into a plan that's yours
The info above is free. Membership makes it personal, the Coach answers questions about your exact stack, the Stack tracks it for you, and the Verified Sources shows you how to vet what you buy.
- ✓ AI Coach, ask anything about your stack. It does the dosing math, flags interactions, and tells you what to do next.
- ✓ Personal Stack, save your protocol, track it across devices, log doses, get a heads-up before a vial runs out.
- ✓ Verified Sources, the vetted reference for checking quality and sourcing, members only.
Cancel anytime · or save with $59.99/yr · Coach + Stack included