Trestolone
MENT / 7-alpha-methyl-19-nortestosterone · Anabolic steroid (injectable)
What it is
A nortestosterone derivative studied clinically for male contraception — it suppresses sperm production near-completely, which was the design goal. It has since appeared in non-medical physique use far outside the studied context.
What human evidence shows
Legitimate but narrow: contraception and hypogonadism studies confirm potent androgenic/anabolic activity. Physique use runs far beyond studied exposures with no data at all.
Risks
Aromatizes readily — estrogen-driven side effects are a common reported failure mode. Suppression of sperm production is the drug's designed purpose, and recovery timelines outside trial-monitored exposures are uncharted. Lipid, blood-pressure, and cardiac strain are expected class effects.
Legal status
US: Schedule III anabolic steroid under the CSA; never approved for any indication.
Evidence base
emerging literature
Early human evidence: at least one human trial report, and not much beyond it.
- phase 3/4
- 0
- randomised
- 2
- reviews
- 0
- human trials
- 3
Counts are of published papers, not distinct trials, and measure how much research exists — not whether this works or is safe for you.
Research (12)
- Potential interaction between exogenous anabolic steroids and sugammadex: failed reversal of rocuronium in a patient taking testosterone and trestolone acetateAnaesth Rep · 2023
- Comment on 'Potential interaction between exogenous anabolic steroids and sugammadex: failed reversal of rocuronium in a patient taking testosterone and trestolone acetate'Anaesth Rep · 2024
- Investigations Into the Human Metabolism of Trestolone (7α-Methyl-19-Nortestosterone)Drug Test Anal · 2026
- Androgen replacement therapy: present and futureDrugs · 2004
- Male contraception: expanding reproductive choiceIndian J Exp Biol · 2005
- Hormonal contraception in the maleBr Med Bull · 2000
- 7α-methyl-19-nortestosterone (MENTR): the population council's contribution to research on male contraception and treatment of hypogonadismContraception · 2013
- 7 alpha-methyl-nortestosterone (MENT): the optimal androgen for male contraceptionAnn Med · 1993
- Androgen and Luteinizing Hormone Stimulate the Function of Rat Immature Leydig Cells Through Different Transcription SignalsFront Endocrinol (Lausanne) · 2021
- 7 alpha-Methyl-19-nortestosterone: an ideal androgen for replacement therapyRecent Prog Horm Res · 1994
- Reversal of testicular function after prolonged suppression with an LHRH agonist in rhesus monkeysJ Androl · 1987
- 7Alpha-methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal menJ Clin Endocrinol Metab · 1999
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