What are the side effects of GHRP-2 / GHRP-6?
The most commonly reported GHRP-2 / GHRP-6 side effects are gHRP-6: aggressive hunger 30-60 min post-dose, gHRP-2: cortisol and prolactin bumps, head-rush at injection. Most are mild and tend to be dose dependent. It is generally avoided with active malignancy. Human clinical evidence for GHRP-2 / GHRP-6 is limited, so this reflects reported and observed effects, not a complete safety profile.
Reported GHRP-2 / GHRP-6 side effects
- GHRP-6: aggressive hunger 30-60 min post-dose
- GHRP-2: cortisol and prolactin bumps
- Head-rush at injection
- Receptor desensitization with chronic use
Who should avoid it
- Active malignancy
- Pregnancy / nursing
Bloodwork worth tracking
- IGF-1 baseline + week 8
- Prolactin if running >8 weeks (GHRP-2)
References
- Effects of GH-releasing peptide-2 (GHRP-2) on body composition — Bowers CY et al., JCEM, 2004
- Estradiol regulates GH-releasing peptide's interactions with GH-releasing hormone and somatostatin in postmenopausal women — Norman C et al., European Journal of Endocrinology, 2014
- Growth hormone-independent cardiotropic activities of growth hormone-releasing peptides in normal subjects, in patients with growth hormone deficiency, and in patients with idiopathic or ischemic dilated cardiomyopathy — Broglio F et al., Endocrine, 2001
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.