What is the half-life of KPV?
KPV has a reported half life of ~hours (poorly characterized), given oral, sub-q, or topical. That is why it is typically dosed daily. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~hours (poorly characterized)
- Route: Oral, sub-q, or topical
- Typical schedule: Daily
- Cycle length: 4-8 weeks
References
- Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease — Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Böhm M, Luger TA, Domschke W, Kucharzik T — Inflammatory Bowel Diseases, 2008;14(3):324-31
- Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis — Xiao B, Xu Z, Viennois E, et al. — Molecular Therapy, 2017;25(7):1628-1640
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.