What is the half-life of Thymosin Alpha-1 (Tα1)?
Thymosin Alpha-1 (Tα1) has a reported half life of ~2 hours, given subcutaneous. That is why it is typically dosed 1-2x weekly. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~2 hours
- Route: Subcutaneous
- Typical schedule: 1-2x weekly
- Cycle length: 4-8 weeks
References
- Thymosin alpha 1 in chronic hepatitis B and C — Sherman KE et al., Gut, 2003
- The efficacy and safety of thymosin alpha1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial — Wu J et al., BMJ, 2025
- The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial — Wu J et al., Critical Care, 2013
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.