What are the side effects of Tirzepatide?
The most commonly reported Tirzepatide side effects are nausea, constipation, reflux. Most are mild and tend to be dose dependent. It is generally avoided with mTC / MEN-2 history. Human clinical evidence for Tirzepatide is limited, so this reflects reported and observed effects, not a complete safety profile.
Reported Tirzepatide side effects
- Nausea
- Constipation
- Reflux
- Fatigue
- Underrating protein intake
Who should avoid it
- MTC / MEN-2 history
- Pancreatitis history
- Pregnancy / nursing
Bloodwork worth tracking
- Lipid panel
- ALT/AST
- A1C if relevant
References
- Tirzepatide Once Weekly for Treatment of Obesity (SURMOUNT-1) — Jastreboff AM et al., NEJM, 2022
- Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2) — Frías et al., N Engl J Med, 2021
- Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial — Garvey et al., Lancet, 2023
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.