PEA
Palmitoylethanolamide · Inflammation
An endogenous fatty-acid amide studied in chronic pain — modest reported benefit, limited adverse-event reporting.
What the evidence says
Meta-analyses in chronic and neuropathic pain report possible pain reduction, but the underlying studies are small and heterogeneous, several come from one research cluster using one branded form, and adverse-event reporting is limited — so the evidence base is narrower than its size suggests.
What studies used
Most trials used 300–600 mg twice daily (micronized forms dominate the literature). Trials typically assessed effects after several weeks of daily use.
Reported from published studies and product labelling — a record of what was used in research, not a recommendation. What is right for you is a conversation with a clinician.
Watch out for
- Trial durations ran weeks, not days — short-term impressions say little either way
- Quality varies; the trial evidence is mostly on micronized/ultramicronized material
Evidence base
established literature
Large human evidence base: several phase 3 or 4 trial reports, plus multiple meta-analyses or systematic reviews.
This letter measures how much human research exists, not whether it works for you — the tier above (Moderate) is the read on quality.
Research (12)
- Composition, physicochemical properties of pea protein and its application in functional foodsCrit Rev Food Sci Nutr · 2020
- Pea protein composition, functionality, modification, and food applications: A reviewAdv Food Nutr Res · 2022
- Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer's DiseaseFront Pharmacol · 2019
- The Current Situation of Pea Protein and Its Application in the Food IndustryMolecules · 2022
- Unveiling pseudo-pulseless electrical activity (pseudo-PEA) in ultrasound-integrated infant resuscitationEur J Pediatr · 2023
- Structural properties of pea proteins (Pisum sativum) for sustainable food matricesCrit Rev Food Sci Nutr · 2024
- Understanding Starch Metabolism in Pea Seeds towards Tailoring Functionality for Value-Added UtilizationInt J Mol Sci · 2021
- Advances in pea protein-based films for food applications: A comprehensive reviewFood Res Int · 2025
- A Comprehensive Review of Pea (Pisum sativum L.): Chemical Composition, Processing, Health Benefits, and Food ApplicationsFoods · 2023
- On the Quest of Cellular Functions of PEA-15 and the Therapeutic OpportunitiesPharmaceuticals (Basel) · 2015
- Anthocyanins From Clitoria ternatea Flower: Biosynthesis, Extraction, Stability, Antioxidant Activity, and ApplicationsFront Plant Sci · 2021
- A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative ReviewPain Ther · 2025
Turn PEA into a plan that's yours
The info above is free. Membership makes it personal, the Coach answers questions about your exact stack, the Stack tracks it for you, and the Verified Sources shows you how to vet what you buy.
- ✓ AI Coach, ask anything about your stack. It does the dosing math, flags interactions, and tells you what to do next.
- ✓ Personal Stack, save your protocol, track it across devices, log doses, get a heads-up before a vial runs out.
- ✓ Verified Sources, the vetted reference for checking quality and sourcing, members only.
Cancel anytime · or save with $59.99/yr · Coach + Stack included